MMP26 and IGFBP1

Number of citations of the paper that reports this interaction (PubMedID 12119297)
0

Data Source:
HPRD (in vitro, in vivo)

		MMP26	IGFBP1
Description		matrix metallopeptidase 26	insulin like growth factor binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Proteolysis Extracellular Matrix Organization Collagen Catabolic Process Negative Regulation Of Inflammatory Response	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Growth Response To Insulin Tissue Regeneration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Marimastat
Diseases
GWAS		Coenzyme Q10 levels ( 27149984) Malaria ( 31844061) Mean corpuscular volume ( 28453575)	Major depressive disorder ( 23377640) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 28135244 30487518) Rheumatoid arthritis ( 21156761) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27618447)
Interacting Genes		4 interacting genes: ERRFI1 IGFBP1 MMP9 SERPINA1	4 interacting genes: IGF1 IGF2 MMP26 TF
Entrez ID		56547	3484
HPRD ID		05683	00897
Ensembl ID		ENSG00000167346	ENSG00000146678
Uniprot IDs		A0A8J8YUH5 Q9NRE1	P08833
PDB IDs			1ZT3 1ZT5 2DSQ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Embryo Implantation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Response To Insulin Ficolin-1-rich Granule Lumen Regulation Of Epithelial Cell Differentiation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Skeletal System Development Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Negative Regulation Of Signal Transduction Insulin-like Growth Factor I Binding Response To Peptide Hormone Negative Regulation Of Cell Communication Insulin-like Growth Factor Binding Insulin-like Growth Factor II Binding Negative Regulation Of Signaling Extracellular Space Endoplasmic Reticulum Lumen Response To UV-A Positive Regulation Of Keratinocyte Migration Regulation Of Protein Phosphorylation Cellular Response To UV-A Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Lung Vasculature Development Limb Joint Morphogenesis Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Extracellular Matrix Regulation Of Phosphorylation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Lung Epithelium Development Cellular Response To Lipid Cellular Hyperosmotic Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of DNA Binding Cellular Response To Platelet-derived Growth Factor Stimulus	Exocrine Pancreas Development Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Binding Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Glycogen Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Extracellular Space Platelet Alpha Granule Lumen Striated Muscle Cell Differentiation Insulin Receptor Signaling Pathway Regulation Of Organ Growth Regulation Of Glucose Metabolic Process Positive Regulation Of T Cell Proliferation Muscle Cell Differentiation Negative Regulation Of Oocyte Development Extracellular Region Hormone Activity Regulation Of Mitotic Nuclear Division Receptor Ligand Activity Osteoblast Differentiation Regulation Of Generation Of Precursor Metabolites And Energy Integrin Binding Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Trophectodermal Cell Proliferation Growth Factor Activity Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Nuclear Division Regulation Of Muscle Cell Differentiation Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Developmental Growth Positive Regulation Of Leukocyte Proliferation Regulation Of T Cell Proliferation Insulin-like Growth Factor Binding Protein Complex Glycolate Metabolic Process Negative Regulation Of Inflammatory Response Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Alphav-beta3 Integrin-IGF-1-IGF1R Complex Prostate Gland Stromal Morphogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Type B Pancreatic Cell Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?