ATF6B and MBTPS2

Number of citations of the paper that reports this interaction (PMID 11163209)
293

Data Source:
HPRD (in vivo)

		ATF6B	MBTPS2
Gene Name		activating transcription factor 6 beta	membrane-bound transcription factor peptidase, site 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Protein-DNA Complex	Golgi Membrane Cytoplasm Integral Component Of Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Metalloendopeptidase Activity Metal Ion Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725) Prostate cancer ( 23535732)
Protein-Protein Interactions		9 interactors: ATF6 CDK6 CREBZF MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1	1 interactors: ATF6B
Entrez ID		1388	51360
HPRD ID		02992	02243
Ensembl ID		ENSG00000213676	ENSG00000012174
Uniprot IDs		Q6AZW6 Q99941	O43462
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Positive Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Kinase Activity Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Kinase Activity Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Transcription, DNA-templated RNA Biosynthetic Process Membrane Protein Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Regulation Of DNA-templated Transcription In Response To Stress Regulation Of RNA Metabolic Process Positive Regulation Of Protein Modification Process RNA Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lactation Locus Ceruleus Development Cell Dedifferentiation Trochlear Nerve Formation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress
Tagcloud ?			adaptation anterior atf4 bip carbohydrates chop consuming disrupt fat flexors inducers ire1alpha mtorc1 muscles myogenic overload palmitic plantar s6k1 soleus spliced thapsigargin tibialis tunicamycin unfolded unspliced upr wk xbp1
Tagcloud (Difference) ?			adaptation anterior atf4 bip carbohydrates chop consuming disrupt fat flexors inducers ire1alpha mtorc1 muscles myogenic overload palmitic plantar s6k1 soleus spliced thapsigargin tibialis tunicamycin unfolded unspliced upr wk xbp1
Tagcloud (Intersection) ?