ATF6B and PHOX2A

Number of citations of the paper that reports this interaction (PubMedID 10644760)
0

Data Source:
HPRD (in vitro)

		ATF6B	PHOX2A
Description		activating transcription factor 6 beta	paired like homeobox 2A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of ATF6-mediated Unfolded Protein Response	Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Somatic Motor Neuron Differentiation Oculomotor Nerve Formation Trochlear Nerve Formation Locus Ceruleus Development Midbrain Development Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Parasympathetic Nervous System Development Neuron Development Dopaminergic Neuron Differentiation
Pathways		ATF6B (ATF6-beta) activates chaperones ATF6B (ATF6-beta) activates chaperones
Drugs
Diseases			Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		A body shape index ( 34021172) Age-related macular degeneration ( 23577725) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 32469254) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: ATF6 CDK6 CREBZF LHX8 MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1	5 interacting genes: ATF6B CREBBP HAND2 JUN PRKACA
Entrez ID		1388	401
HPRD ID		02992	04129
Ensembl ID		ENSG00000213676	ENSG00000165462
Uniprot IDs		A0A1U9X796 Q6AZW6 Q99941	O14813
PDB IDs
Enriched GO Terms of Interacting Partners?		ATF6-mediated Unfolded Protein Response ER-nucleus Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response RNA Polymerase II Transcription Regulator Complex Response To Endoplasmic Reticulum Stress Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CCAAT-binding Factor Complex Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Regulation Of G2/M Transition Of Mitotic Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Lipid Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process NLS-bearing Protein Import Into Nucleus Cellular Response To Stress Neuron Development Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Regulation Of Lipid Biosynthetic Process Membrane Protein Proteolysis Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Steroid Biosynthetic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress	Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Embryonic Digit Morphogenesis Transcription Coactivator Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Outflow Tract Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Cellular Response To Stress Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of Signaling Histone H3K27 Acetyltransferase Activity Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Negative Regulation Of ATF6-mediated Unfolded Protein Response Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Polymerase II Transcription Regulator Complex Leading Edge Cell Differentiation Primary Palate Development Positive Regulation Of Semaphorin-plexin Signaling Pathway Cell Proliferation Involved In Outflow Tract Morphogenesis Visceral Serous Pericardium Development Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Intracellular Signal Transduction Cellular Response To Anisomycin Regulation Of Osteoblast Differentiation Regulation Of Semaphorin-plexin Signaling Pathway Intracellular Signaling Cassette Regulation Of ATF6-mediated Unfolded Protein Response Response To Anisomycin Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
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