MAP3K21

Description		mitogen-activated protein kinase kinase kinase 21
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GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: CLK1 MAP3K11 STUB1
Entrez ID		84451
HPRD ID		10087
Ensembl ID		ENSG00000143674
Uniprot IDs		Q5TCX8
PDB IDs		4UYA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chaperone-mediated Protein Complex Assembly Protein Serine/threonine Kinase Activity Transferase Activity Protein Serine Kinase Activity Protein Kinase Activity Mitogen-activated Protein Kinase Kinase Binding Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process JUN Kinase Kinase Kinase Activity Positive Regulation Of JUN Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding MAPK Cascade Chaperone-mediated Autophagy Positive Regulation Of ERAD Pathway Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Vasoconstriction Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Contraction Response To Misfolded Protein Cellular Response To Misfolded Protein TPR Domain Binding Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Misfolded Protein Binding Negative Regulation Of Smooth Muscle Contraction Kinase Activity Regulation Of Protein Modification Process MAP Kinase Kinase Kinase Activity Negative Regulation Of Muscle Contraction ERBB2 Signaling Pathway Positive Regulation Of Mitophagy Protein Serine/threonine/tyrosine Kinase Activity Protein Homodimerization Activity Positive Regulation Of Autophagy Of Mitochondrion Regulation Of ERAD Pathway Cellular Response To Topologically Incorrect Protein R-SMAD Binding Protein Folding Chaperone Complex Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Hormone Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy
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