MAP3K11 and TIA1

		MAP3K11	TIA1
Description		mitogen-activated protein kinase kinase kinase 11	TIA1 cytotoxic granule associated RNA binding protein
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Stress Granule Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation	Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Cytokine Production MRNA Processing Apoptotic Process RNA Splicing Negative Regulation Of Translation Stress Granule Assembly Regulation Of MRNA Splicing, Via Spliceosome Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants	FGFR2 alternative splicing
Drugs		Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)	Acne (severe) ( 24927181) Male-pattern baldness ( 28196072)
Interacting Genes		29 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 DSCAM EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 LATS1 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6	2 interacting genes: FASTK WBP4
Entrez ID		4296	7072
HPRD ID		02502	04626
Ensembl ID		ENSG00000173327	ENSG00000116001
Uniprot IDs		Q16584	E5RGV5 F8W8I6 P31483
PDB IDs		5K26 5K28 6AQB 6CQ7	2MJN 3BS9 5ITH 5O2V 5O3J 6ELD 7VI4 7VI5
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette MAPK Cascade Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Postsynapse Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Nucleotide Binding Kinesin II Complex MAP-kinase Scaffold Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axo-dendritic Transport Protein Kinase Binding Protein Serine Kinase Activity Regulation Of Apoptotic Process Protein Kinase Activity Transport Along Microtubule Regulation Of Programmed Cell Death Signal Transduction Glutamatergic Synapse Cytoskeleton-dependent Intracellular Transport Fc-epsilon Receptor Signaling Pathway Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction ATP Binding Microtubule-based Transport Kinase Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Regulation Of Postsynapse Organization Cell Projection Organization CD40 Receptor Complex Anterograde Dendritic Transport JUN Kinase Binding Regulation Of Phosphorus Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphorylation Photoreceptor Connecting Cilium Kinesin Binding Kinesin Complex Establishment Of Vesicle Localization Cytoplasm	Fas-activated Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Kinase Binding Phosphorylation Protein Serine Kinase Activity Protein Phosphorylation JUN Kinase Kinase Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Mitochondrial MRNA Stability Kinase Activity Positive Regulation Of JUN Kinase Activity MAP Kinase Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ribonucleoprotein Granule Mitochondrial RNA Processing Precatalytic Spliceosome Proline-rich Region Binding MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MAP Kinase Activity
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