TIA1

Description		TIA1 cytotoxic granule associated RNA binding protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Stress Granule Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Cytokine Production MRNA Processing Apoptotic Process RNA Splicing Negative Regulation Of Translation Stress Granule Assembly Regulation Of MRNA Splicing, Via Spliceosome Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways		FGFR2 alternative splicing
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Male-pattern baldness ( 28196072)
Novel Interacting Genes		1 novel interacting genes: MAP3K11
Interacting Genes		2 interacting genes: FASTK WBP4
Entrez ID		7072
HPRD ID		04626
Ensembl ID		ENSG00000116001
Uniprot IDs		E5RGV5 F8W8I6 P31483
PDB IDs		2MJN 3BS9 5ITH 5O2V 5O3J 6ELD 7VI4 7VI5
Enriched GO Terms of Interacting Partners?		Fas-activated Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Kinase Binding Phosphorylation Protein Serine Kinase Activity Protein Phosphorylation JUN Kinase Kinase Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Mitochondrial MRNA Stability Kinase Activity Positive Regulation Of JUN Kinase Activity MAP Kinase Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ribonucleoprotein Granule Mitochondrial RNA Processing Precatalytic Spliceosome Proline-rich Region Binding MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MAP Kinase Activity
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