MFNG and DLL1

Number of citations of the paper that reports this interaction (PMID 12036964)
36

Data Source:
HPRD (in vivo)

		MFNG	DLL1
Gene Name		MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	delta-like 1 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Golgi Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Metal Ion Binding	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Pattern Specification Process Metabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Notch Signaling Pathway	Cell Fate Determination Somite Specification Heart Looping Notch Signaling Pathway Notch Receptor Processing Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Hemopoiesis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Interleukin-10 Production Negative Regulation Of Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development Left/right Axis Specification Proximal Tubule Development Loop Of Henle Development Neuronal Stem Cell Maintenance
Pathways		Pre-NOTCH Processing in Golgi Signaling by NOTCH Pre-NOTCH Expression and Processing	Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS			Type 1 diabetes ( 21980299)
Protein-Protein Interactions		4 interactors: DLL1 JAG1 NOTCH1 NOTCH2	10 interactors: ADAM10 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 NOV POFUT1 PSEN1
Entrez ID		4242	28514
HPRD ID		03988	05957
Ensembl ID		ENSG00000100060	ENSG00000198719
Uniprot IDs		O00587	O00548
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Notch Signaling Pathway Stem Cell Maintenance Neuronal Stem Cell Maintenance Heart Morphogenesis Heart Valve Morphogenesis Heart Valve Development Stem Cell Development Cell Fate Commitment Stem Cell Differentiation Cell Fate Determination Cardiac Septum Morphogenesis Morphogenesis Of An Epithelial Sheet Cardiac Septum Development Ciliary Body Morphogenesis Compartment Pattern Specification Morphogenesis Of An Epithelium Heart Development Renal Tubule Development Determination Of Left/right Symmetry Sensory Organ Development Determination Of Bilateral Symmetry Interleukin-4 Secretion Tissue Morphogenesis Cardiac Chamber Development Nephron Development Negative Regulation Of Cell Differentiation Kidney Epithelium Development Interleukin-4 Production Loop Of Henle Development Distal Tubule Development Left/right Axis Specification Cardiovascular System Development Inner Ear Development Negative Regulation Of Neuron Differentiation Organ Morphogenesis Response To Muramyl Dipeptide Ear Development Cardiac Right Ventricle Morphogenesis Epithelium Development Left/right Pattern Formation Negative Regulation Of Neurogenesis Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Signal Transduction Kidney Development Cardiac Atrium Morphogenesis Auditory Receptor Cell Differentiation Renal System Development	Notch Receptor Processing Notch Signaling Pathway Nervous System Development Anatomical Structure Morphogenesis Pattern Specification Process Blood Vessel Development Vasculature Development Epithelium Development Glomerulus Development Cell Surface Receptor Signaling Pathway Cell Fate Commitment Multicellular Organismal Development Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Interleukin-4 Production Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Generation Of Neurons Cardiovascular System Development Developmental Process Neurogenesis Membrane Protein Ectodomain Proteolysis Tissue Development Nephron Development System Development Cell Development Embryonic Limb Morphogenesis Myeloid Dendritic Cell Differentiation Glomerulus Vasculature Development Morphogenesis Of An Epithelium Heart Development Transcription Initiation From RNA Polymerase II Promoter Organ Development Myeloid Dendritic Cell Activation Neuron Differentiation Limb Morphogenesis Regulation Of Neuron Differentiation Embryo Development Negative Regulation Of Neuron Differentiation Limb Development Regulation Of Cell Migration Membrane Protein Proteolysis Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Morphogenesis Regulation Of Cell Motility
Tagcloud ?			ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic notch notch1 pericytes played potentiate regenerate regenerative satellite tuning
Tagcloud (Difference) ?			ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic notch notch1 pericytes played potentiate regenerate regenerative satellite tuning
Tagcloud (Intersection) ?