MAZ and DCC

Number of citations of the paper that reports this interaction (PMID 12509857)
5

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MAZ	DCC
Gene Name		MYC-associated zinc finger protein (purine-binding transcription factor)	DCC netrin 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytosol Plasma Membrane Integral Component Of Membrane Axon Growth Cone Membrane Membrane Raft
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Chromatin Binding Protein Binding Poly(A) RNA Binding Metal Ion Binding	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter	Neuron Migration Response To Amphetamine Apoptotic Process Axonogenesis Axon Guidance Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Collateral Sprouting Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Regulation Of Neuron Death Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Dendrite Development
Pathways			DSCAM interactions Axon guidance Role of second messengers in netrin-1 signaling DCC mediated attractive signaling Programmed Cell Death Netrin mediated repulsion signals Netrin-1 signaling Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS			Alcoholism (alcohol use disorder factor score) ( 21529783) Body mass index (interaction) ( 23192594) Gallbladder cancer ( 22318345) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: BPTF CSNK2A1 DCC	16 interactors: ADORA2B APPL1 AR BARD1 CASP3 CASP9 MAPK3 MAZ NCK1 NTN1 PITPNA PTK2 PTK2B RPL5 SIAH1 SIAH2
Entrez ID		4150	1630
HPRD ID		02999	00391
Ensembl ID		ENSG00000103495
Uniprot IDs		H3BQD6 P56270 Q59GP8	P43146 Q49AK4
PDB IDs			2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4
Enriched GO Terms of Interacting Partners?		Netrin-activated Signaling Pathway Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Regulation Of Cell Growth Negative Regulation Of Collateral Sprouting Axon Guidance Nervous System Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Negative Regulation Of Dendrite Development Regulation Of Growth Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Positive Regulation Of Metabolic Process Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Response To Amphetamine Neuron Development Apoptotic Process Mitotic Spindle Checkpoint Central Nervous System Development Central Nervous System Projection Neuron Axonogenesis Negative Regulation Of Chromosome Segregation Programmed Cell Death System Development Cell Death Death Cell Morphogenesis Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Response To Amine Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Metaphase/anaphase Transition Neuron Differentiation Regulation Of RNA Metabolic Process Cell Projection Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chaperone-mediated Protein Folding Negative Regulation Of Axonogenesis Locomotion Multicellular Organismal Development Central Nervous System Neuron Axonogenesis Positive Regulation Of Signal Transduction Negative Regulation Of Proteasomal Protein Catabolic Process	Cell Morphogenesis Involved In Differentiation Apoptotic Process Axon Guidance Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Cell Morphogenesis Regulation Of Cell Death Neuron Differentiation Signal Complex Assembly Neuron Projection Development Axonogenesis Cell Development Response To External Stimulus Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Projection Organization Neurogenesis Positive Regulation Of Protein Metabolic Process Locomotion Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process ERBB Signaling Pathway Nervous System Development Regulation Of Protein Kinase Activity Glial Cell Apoptotic Process Regulation Of Kinase Activity System Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process
Tagcloud ?		1a 1b begin commitment construct dnase encodes erythroid ets gata helix hypersensitive inactivity joint lineage lineages mast megakaryocytic motifs multipotent nonexpressing progenitors promoter reflected repressed restricted scl transactivate weakly	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		1a 1b begin commitment construct dnase encodes erythroid ets gata helix hypersensitive inactivity joint lineage lineages mast megakaryocytic motifs multipotent nonexpressing progenitors promoter reflected repressed restricted scl transactivate weakly	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?