TBC1D3C and CLIC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D3C	CLIC3
Description		TBC1 domain family member 3C	chloride intracellular channel 3
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane	Extracellular Region Nucleus Cytoplasm Plasma Membrane Membrane Nuclear Body Extracellular Matrix Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome
	Molecular Function	GTPase Activator Activity	Chloride Channel Activity Protein Binding Oxidoreductase Activity Protein-disulfide Reductase (glutathione) Activity
	Biological Process		Monoatomic Ion Transport Chloride Transport Signal Transduction Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Sprouting Angiogenesis
Pathways		TBC/RABGAPs
Drugs
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		3 interacting genes: CLIC3 RAB5A ZRANB1	35 interacting genes: AGR2 ALX1 ANKRD23 ANKRD55 APP CIMIP2B DDIT4L DNM1 EFHC2 GLYR1 INCA1 KATNBL1 KRT85 KRTAP13-3 LELP1 MAPK15 MBD3L1 MECOM MIA3 MSX2 POT1 PROSER2 SCML4 SPMIP4 SPMIP6 STMN3 TBC1D3 TBC1D3C TBC1D3K TEPSIN TLE5 VPS4A ZBTB42 ZC2HC1C ZNF620
Entrez ID		414060	9022
HPRD ID		17559	05941
Ensembl ID		ENSG00000278299	ENSG00000169583
Uniprot IDs		Q6IPX1 Q8IZP1	O95833
PDB IDs			3FY7 3KJY
Enriched GO Terms of Interacting Partners?		Cytoplasmic Side Of Early Endosome Membrane Wnt Signaling Pathway Protein Localization To Early Endosome Protein-disulfide Reductase (glutathione) Activity Protein K33-linked Deubiquitination Protein K29-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Clearance By Transcytosis Regulation Of Endosome Size Plasma Membrane To Endosome Transport Early Phagosome Transcytosis Somatodendritic Compartment Guanyl Nucleotide Binding Regulation Of Vesicle Size Synaptic Vesicle Recycling Protein Localization To Endosome Early Endosome To Late Endosome Transport Amyloid-beta Clearance Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Sprouting Angiogenesis Protein K63-linked Deubiquitination Deubiquitinase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
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