MAN2A2 and ENO3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MAN2A2	ENO3
Description		mannosidase alpha class 2A member 2	enolase 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Phosphopyruvate Hydratase Complex Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Catalytic Activity Alpha-mannosidase Activity Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase Activity Protein Binding Mannosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Carbohydrate Binding Metal Ion Binding	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Mannose Metabolic Process Protein Glycosylation N-glycan Processing	Gluconeogenesis Glycolytic Process Canonical Glycolysis
Pathways		Intra-Golgi traffic Reactions specific to the complex N-glycan synthesis pathway	Glycolysis Gluconeogenesis
Drugs			2-phospho-D-glyceric acid Phosphoenolpyruvate 2-Phosphoglycolic Acid Phosphonoacetohydroxamic Acid
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee ( 33287642) Schizophrenia ( 25056061 29483656)	Keratoconus ( 33649486) Red cell distribution width ( 32888494)
Interacting Genes		6 interacting genes: CHD3 ELP1 ENO3 GIT1 LUC7L2 VIM	20 interacting genes: ALDOA APP DCTN1 DSP HSPB2 KALRN LINC01554 MAN2A2 MTMR14 NEB PGM1 PKM PNKD SGCG SNAPIN SPTB TCAP TRAPPC2 TRIM63 TTN
Entrez ID		4122	2027
HPRD ID		02994	11746
Ensembl ID		ENSG00000196547	ENSG00000108515
Uniprot IDs		A0A0C4DGL1 H0YNG5 P49641	P13929
PDB IDs			2XSX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Microtubule Polymerization Centrosome Cycle Regulation Of Microtubule Polymerization Scaffold Protein Binding Negative Regulation Of ARF Protein Signal Transduction Microtubule Organizing Center Organization Positive Regulation Of Protein Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Focal Adhesion Cellular Response To Lipid Structural Constituent Of Postsynaptic Specialization	M Band I Band Titin-telethonin Complex Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Cytoplasm Somatic Muscle Development Myosin Filament Assembly Actin Cytoskeleton Supramolecular Fiber Organization Z Disc Structural Constituent Of Muscle Skeletal Muscle Thin Filament Assembly Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Detection Of Muscle Stretch Hexose Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Cardiac Muscle Tissue Morphogenesis Monosaccharide Metabolic Process Pyruvate Metabolic Process Muscle Contraction Muscle Tissue Morphogenesis Ribonucleoside Diphosphate Metabolic Process Neuron Projection Maintenance Contractile Muscle Fiber Titin Binding Purine Ribonucleotide Catabolic Process Axo-dendritic Transport Striated Muscle Contraction Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process System Process Cardiac Myofibril Assembly Muscle Filament Sliding Actin-myosin Filament Sliding Muscle System Process Actin Filament Organization Nucleotide Catabolic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Cardiac Muscle Hypertrophy Ficolin-1-rich Granule Lumen Response To Muscle Stretch Nucleoside Phosphate Catabolic Process Cytosol Muscle Hypertrophy
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