MIR20A and EDC4

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR20A	EDC4
Description		microRNA 20a	enhancer of mRNA decapping 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Vesicle	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Protein Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Outflow Tract Morphogenesis Inflammatory Response Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Cardioblast Proliferation Positive Regulation Of Pulmonary Blood Vessel Remodeling	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways			mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS			HDL cholesterol ( 21347282) Metabolic syndrome ( 22399527) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		73 interacting genes: AIMP2 APOBEC3B C1QBP CRTAP DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 DZIP3 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC LSM10 LSM11 MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 RARS1 RBM14 RBM4 RTCB SF3B1 SF3B2 SF3B3 SFPQ SUGP2 SYNCRIP TAF15 TIAL1 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3 ZNF346	42 interacting genes: CCL5 CDC42 CEBPA EIF2AK2 FBLN1 FXR1 FXR2 GIT2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR122 MIR128-2 MIR141 MIR15B MIR199A1 MIR200A MIR200B MIR200C MIR205 MIR20A MIR21 MIR214 MIR222 MIR29C MIR34A MIR34C MIR363 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E SNCA SUMO2 YTHDC1
Entrez ID		406982	23644
HPRD ID			06911
Ensembl ID		ENSG00000283762	ENSG00000038358
Uniprot IDs			A0A8B0RAT7 Q6P2E9
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Splicing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Macromolecule Metabolic Process Nucleoplasm Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Catalytic Step 2 Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of Translation MRNA 3'-UTR Binding Regulation Of MRNA Processing Negative Regulation Of MRNA Metabolic Process MiRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of Cytoplasmic Translation Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Stabilization Positive Regulation Of Gene Expression Regulation Of MRNA Stability Positive Regulation Of Translation Regulation Of RNA Stability Nucleolus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process P-body Positive Regulation Of Biosynthetic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization Regulation Of Translation RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Protein Metabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Signal Transduction Extracellular Space Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Angiogenesis Regulation Of Protein Metabolic Process Negative Regulation Of Vasculature Development Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Catabolic Process Regulation Of Angiogenesis Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Population Proliferation Regulation Of Vasculature Development
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