MIR16-2 and HARS2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR16-2	HARS2
Description		microRNA 16-2	histidyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function		Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Histidine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	MiRNA-mediated Post-transcriptional Gene Silencing	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation Mitochondrial Translation
Pathways			Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Malaria ( 31844061)	Aspartate aminotransferase levels ( 33547301) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		83 interacting genes: ADARB1 APOBEC3B ATXN2L C1QBP CPSF1 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RBMS1 RBMS2 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM25 UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H7A ZC3H7B ZFR ZNF346	22 interacting genes: AGTRAP BST2 MIR106B MIR128-2 MIR141 MIR145 MIR16-2 MIR17 MIR18B MIR199A1 MIR19B1 MIR19B2 MIR29A MIR29B1 MIR34A MIR34B MIR9-1 MIR92A2 MIR93 MIRLET7F1 MIRLET7I OGT
Entrez ID		406951	23438
HPRD ID			02871
Ensembl ID		ENSG00000198987	ENSG00000112855
Uniprot IDs			A0A2R8Y5P7 A0A2R8Y6I1 B4DDN8 P49590
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Nucleus Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Nucleoplasm Spliceosomal Complex Cytoplasmic Stress Granule MiRNA Binding MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Catalytic Step 2 Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Negative Regulation Of MRNA Catabolic Process Negative Regulation Of Translation RNA Stabilization Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Ligase Activity TRNA Aminoacylation Regulation Of Macromolecule Metabolic Process MRNA Stabilization Positive Regulation Of Cytoplasmic Translation Regulation Of Primary Metabolic Process CRD-mediated MRNA Stabilization Regulation Of Metabolic Process MRNA 5'-UTR Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process TRNA Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cholesterol Efflux Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Developmental Process MRNA Destabilization Regulation Of Translation RNA Destabilization Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cholesterol Transport Positive Regulation Of MRNA Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Extracellular Matrix Assembly Regulation Of Gene Expression Positive Regulation Of Connective Tissue Replacement Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Lipid Transport Negative Regulation Of Transport Negative Regulation Of Signal Transduction Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Connective Tissue Replacement Regulation Of Cholesterol Efflux Regulation Of MRNA Stability Negative Regulation Of Cell Communication
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