MIR143 and CDC5L

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR143	CDC5L
Description		microRNA 143	cell division cycle 5 like
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Exosome	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Cytoplasm Membrane Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding WD40-repeat Domain Binding
	Biological Process	Regulation Of Smooth Muscle Contraction Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization MiRNA-mediated Post-transcriptional Gene Silencing Angiotensin-activated Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Establishment Or Maintenance Of Cell Type Involved In Phenotypic Switching Positive Regulation Of Angiogenesis Negative Regulation Of D-glucose Import Negative Regulation Of Smooth Muscle Cell Proliferation Aorta Smooth Muscle Tissue Morphogenesis Regulation Of Phenotypic Switching Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Pulmonary Blood Vessel Remodeling	DNA Damage Checkpoint Signaling MRNA Splicing, Via Spliceosome DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing DNA Damage Response RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Alzheimer disease and age of onset ( 26830138) Chin dimples ( 27182965) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) FEV1 ( 30804560) Height ( 28552196) Ischemic stroke ( 26089329) Lung function (FVC) ( 30804560) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Nose morphology ( 29921221) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis ( 22763110) Osteoarthritis of the hand ( 28855172) Serum alkaline phosphatase levels ( 33547301) Stroke (ischemic) ( 22941190) Trunk fat mass adjusted for trunk lean mass ( 32239398)
Interacting Genes		79 interacting genes: ADARB1 APOBEC3B C1QBP CDC5L CELF1 CPSF1 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 EPRS1 FAM98A FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TUT4 U2SURP UPF1 UTP20 YBX1 YBX3 ZC3H10	92 interacting genes: AKAP6 AKAP9 ANXA1 BICRAL CALM1 CCDC136 CDC42 CDK2 CDKN1A CDKN2A CDT1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HNRNPM HOOK1 KALRN KANK2 KANSL1 KIF3C KIF5B KRT18 LDOC1 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MIR106B MIR107 MIR143 MIR200B MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR429 MIRLET7A2 MIRLET7D MIRLET7E MIRLET7G MIRLET7I MTUS2 MYT1L OGT ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF3 RNF10 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 SYNPO TP53BP2 TRAF3IP1 TRAK1 TRIO TTF2 TXLNA USHBP1 USP7 VPS52 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1
Entrez ID		406935	988
HPRD ID			04184
Ensembl ID		ENSG00000284182	ENSG00000096401
Uniprot IDs			Q99459
PDB IDs			2DIM 2DIN 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABG 7ABH 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Nucleoplasm Ribonucleoprotein Complex Catalytic Step 2 Spliceosome Spliceosomal Complex MiRNA Binding Regulation Of Gene Expression Regulation Of MRNA Processing Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation MRNA 3'-UTR Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule Regulation Of RNA Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Stabilization Negative Regulation Of Gene Expression Nucleolus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome	MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing RISC Complex DNA Replication Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression DNA Replication Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Origin Recognition Complex Regulation Of DNA Replication Positive Regulation Of Tissue Remodeling Chromosome, Telomeric Region Regulation Of Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Translation Extracellular Vesicle Nuclear Origin Of Replication Recognition Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoskeleton CMG Complex MCM Complex Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Double-strand Break Repair Via Break-induced Replication Negative Regulation Of Transmembrane Transport Regulation Of Cell Cycle Glutamatergic Synapse Regulation Of Connective Tissue Replacement Molecular Adaptor Activity Microtubule Binding Negative Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Protein-containing Complex Assembly
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