MIR138-2 and AIMP1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR138-2	AIMP1
Description		microRNA 138-2	aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Image		No pdb structure
GO Annotations	Cellular Component	RISC Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cell Surface Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function		TRNA Binding RNA Binding Cytokine Activity Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	MiRNA-mediated Post-transcriptional Gene Silencing	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Translation Apoptotic Process Inflammatory Response Signal Transduction Cell-cell Signaling Blood Vessel Morphogenesis Leukocyte Migration Defense Response To Virus Positive Regulation Of Glucagon Secretion
Pathways			Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases			Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS
Interacting Genes		87 interacting genes: AIMP1 AIMP2 APOBEC3B C1QBP CELF1 CPSF1 CPSF6 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DDX49 DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUFIP2 PATL1 PDCD11 PTBP1 PTBP3 PUF60 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM26 TUT7 U2SURP UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF106	51 interacting genes: AIMP2 APP ATP5F1A HOMER1 IQGAP1 LINC01232 MAPK14 MAPK8 MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR15A MIR15B MIR17 MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR205 MIR206 MIR20B MIR214 MIR222 MIR25 MIR29C MIR31 MIR34A MIR34B MIR34C MIR451A MIR7-1 MIR7-2 MIR7-3 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I OPTN RARS1 SUMO2 TSNAX
Entrez ID		406930	9255
HPRD ID			04676
Ensembl ID		ENSG00000207649	ENSG00000164022
Uniprot IDs			B4DNK3 Q12904
PDB IDs			1E7Z 1EUJ 1FL0 4R3Z 8J9S 8ONG
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleus Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleoplasm Ribonucleoprotein Complex Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MiRNA Binding MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of RNA Stability Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of Macromolecule Metabolic Process Nucleolus TRNA Aminoacylation MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Positive Regulation Of Cytoplasmic Translation Ligase Activity Regulation Of Metabolic Process CRD-mediated MRNA Stabilization P-body	Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production MRNA Destabilization Regulation Of Gene Expression RNA Destabilization Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Positive Regulation Of Connective Tissue Replacement Regulation Of Angiogenesis Regulation Of RNA Stability Regulation Of Vasculature Development Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Regulation Of Connective Tissue Replacement Negative Regulation Of Vasculature Development Negative Regulation Of Translation Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Motility Regulation Of Cell Migration Involved In Sprouting Angiogenesis Extracellular Space Negative Regulation Of Locomotion Positive Regulation Of Tissue Remodeling Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
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