LRIG3 and LIMCH1

Number of citations of the paper that reports this interaction (PubMedID 30429017)
0

Data Source:
BioGRID (two hybrid)

		LRIG3	LIMCH1
Description		leucine rich repeats and immunoglobulin like domains 3	LIM and calponin homology domains 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Stress Fiber Cytoplasm Cytoskeleton Actin Cytoskeleton Myosin II Complex
	Molecular Function	Protein Binding Signaling Receptor Activity	Actin Binding Protein Binding Myosin II Head/neck Binding Metal Ion Binding
	Biological Process	Sensory Perception Of Sound Otolith Morphogenesis	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Migration Actomyosin Structure Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Primary Metabolic Process
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Heart failure ( 20445134) Hematocrit ( 29403010) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311)	Deep white matter hyperintensities ( 32517579) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Longevity (90 years and older) ( 25199915) Macular thickness ( 30535121) Optic disc size ( 31809533) Response to statins (LDL cholesterol change) ( 25350695)
Interacting Genes		3 interacting genes: LIMCH1 LMO7 MTDH	2 interacting genes: APP LRIG3
Entrez ID		121227	22998
HPRD ID		08317	11125
Ensembl ID		ENSG00000139263	ENSG00000064042
Uniprot IDs		C9K080 Q6UXM1	B7Z2J4 B7Z656 D6RD46 E9PDJ9 G5EA03 Q9UPQ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Myosin II Head/neck Binding	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Otolith Morphogenesis Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance
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