LIM2 and LGALS3

Number of citations of the paper that reports this interaction (PMID 11532191)
10

Data Source:
HPRD (in vivo)

		LIM2	LGALS3
Gene Name		lens intrinsic membrane protein 2, 19kDa	lectin, galactoside-binding, soluble, 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Cell Junction	Immunological Synapse Proteinaceous Extracellular Matrix Extracellular Space Nucleus Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Eye Lens	Protein Binding IgE Binding Carbohydrate Binding Chemoattractant Activity Laminin Binding Poly(A) RNA Binding
	Biological Process	Cell-cell Junction Assembly	Skeletal System Development Monocyte Chemotaxis MRNA Processing RNA Splicing Extracellular Matrix Organization Neutrophil Chemotaxis Epithelial Cell Differentiation Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Advanced glycosylation endproduct receptor signaling Innate Immune System
Drugs
Diseases
GWAS			Protein biomarker ( 23056639)
Protein-Protein Interactions		1 interactors: LGALS3	20 interactors: APP BARD1 C1GALT1C1 CSNK1A1 CSNK2A1 CSNK2A2 CUBN CYHR1 ELN FCGR2A GEMIN4 GOLGA2 LGALS3BP LIM2 MMP2 MYOC PPIG PRR13 SS18L1 SUFU
Entrez ID		3982	3958
HPRD ID		01097	01090
Ensembl ID		ENSG00000105370	ENSG00000131981
Uniprot IDs		P55344	P17931
PDB IDs			1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4JC1 4JCK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Mononuclear Cell Migration Mononuclear Cell Migration Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Calcium Ion Import Monocyte Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Calcium Ion Import Positive Chemotaxis Regulation Of T Cell Apoptotic Process Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Endocytosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Leukocyte Migration Positive Regulation Of Calcium Ion Transport Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Chemotaxis Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Leukocyte Migration Negative Regulation Of Immune Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Activation Cell Chemotaxis Regulation Of Endocytosis Regulation Of Calcium Ion Transport Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Ion Transport Negative Regulation Of Cell Adhesion Leukocyte Migration Negative Regulation Of Apoptotic Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement RNA Splicing Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization	Neuron Differentiation Neuron Projection Development Negative Regulation Of Cellular Protein Catabolic Process Wnt Signaling Pathway Neuron Development Negative Regulation Of Protein Catabolic Process Endocytosis Generation Of Neurons Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Neurogenesis Cell Projection Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Protein Processing Neuron Maturation Cell Development Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Axonogenesis Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Metaphase/anaphase Transition Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Proteasomal Protein Catabolic Process Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Proteolysis Synaptic Growth At Neuromuscular Junction ERBB2 Signaling Pathway Negative Regulation Of MRNA 3'-end Processing Anatomical Structure Morphogenesis Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Chromosome Organization Collateral Sprouting In Absence Of Injury Mitotic Cell Cycle Extracellular Matrix Disassembly
Tagcloud ?		alpha8 backcross cataract cib collaborative connexin50 cryba1 crybb2 crystallinbetaa3 crystallinbetab2 d11mit31 d3mit22 d5mit88 dnas eu gap gja8 hybrids interspecific juction lens lie locus maps mp19 mp70 ngfg positions synteny	clnd23 clnd8 colorectal cytoscape database david degs detailed differentially downloaded downregulated enriched foxo3 go gse8671 microarray network omnibus ontology pgfdr ppi shed spia string tcf7l2 tfats top upregulated valuable
Tagcloud (Difference) ?		alpha8 backcross cataract cib collaborative connexin50 cryba1 crybb2 crystallinbetaa3 crystallinbetab2 d11mit31 d3mit22 d5mit88 dnas eu gap gja8 hybrids interspecific juction lens lie locus maps mp19 mp70 ngfg positions synteny	clnd23 clnd8 colorectal cytoscape database david degs detailed differentially downloaded downregulated enriched foxo3 go gse8671 microarray network omnibus ontology pgfdr ppi shed spia string tcf7l2 tfats top upregulated valuable
Tagcloud (Intersection) ?