LGALS9 and PDIA6

Number of citations: 121 (PubMedID 31995728)
Data Source: BioGRID (pull down, proximity labelling technology)

		LGALS9	PDIA6
Name		galectin 9	protein disulfide isomerase family A member 6
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Matrix	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Cilium Membrane Centriolar Satellite Endoplasmic Reticulum Chaperone Complex Ciliary Basal Body Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Galactose Binding Galactoside Binding Enzyme Binding Carbohydrate Binding Receptor Ligand Activity Disaccharide Binding Oligosaccharide Binding	Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity Isomerase Activity
	Biological Process	Immune System Process Natural Killer Cell Tolerance Induction Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Female Pregnancy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Lipopolysaccharide Regulation Of Interleukin-4 Production Regulation Of Interleukin-5 Production Negative Regulation Of Chemokine Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway P38MAPK Cascade Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Activated T Cell Proliferation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Maternal Process Involved In Female Pregnancy Positive Regulation Of Activated T Cell Autonomous Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Type II Interferon Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Monocyte Chemotactic Protein-1 Production Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation	Protein Folding Response To Endoplasmic Reticulum Stress
Pathways		Interleukin-2 family signaling	XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		(R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol	None
GWAS		Blood protein levels ( 30072576 ) Crohn's disease ( 23128233 ) Irritable mood ( 29500382 )	Blood protein levels ( 30072576 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Dental caries (decayed, missing and filled teeth) ( 31533690 ) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690 )
Novel Interactors		2 novel interactors: CALCOCO2 OR1D2	3 novel interactors: CEP250 NPC2 THAP1
Interacting Genes		6 interacting genes: CFTR DAZAP2 KRTAP6-3 P4HB PDIA6 RNF13	19 interacting genes: ATP13A2 CASP8 CLN8 CSNK2A1 GET3 LGALS9 LINC01554 MC4R MTNR1A MTNR1B OGT PDE4B SGTB SLC22A2 SLC2A4 SUMO4 TRIM14 UBE3A VKORC1
Entrez ID		3965	10130
HPRD ID		03528	07504
Ensembl ID		ENSG00000168961	ENSG00000143870
Uniprot IDs		O00182	A0A384NPU5 Q15084
PDB IDs		2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6	1X5D 3VWW 3W8J 4EF0 4GWR 8CPQ
GO Terms Enriched among Interactors		Endoplasmic Reticulum Chaperone Complex Isomerase Activity Protein Disulfide Isomerase Activity Protein-disulfide Reductase Activity Response To Endoplasmic Reticulum Stress Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Anion Channel Activity Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Endoplasmic Reticulum-Golgi Intermediate Compartment Melanosome Procollagen-proline 4-dioxygenase Complex Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Peptidyl-proline Hydroxylation Endoplasmic Reticulum Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Interleukin-23-mediated Signaling Pathway Procollagen-proline 4-dioxygenase Activity Thiol Oxidase Activity Xenophagy Positive Regulation Of Autophagosome Maturation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Protein-containing Complex Amelogenesis Protein Folding Insulin Processing Interleukin-12-mediated Signaling Pathway ATPase-coupled Inorganic Anion Transmembrane Transporter Activity	Melatonin Receptor Activity Polyamine Transmembrane Transport Chemical Homeostasis Regulation Of Proteolysis Homeostatic Process Regulation Of Neuron Apoptotic Process Protein Localization To Vacuole Rhythmic Process Neurotransmitter Reuptake Sin3-type Complex