LGALS9 and OR1D2

Data Source: HiPPIP (Novel)

		LGALS9	OR1D2
Name		galectin 9	olfactory receptor family 1 subfamily D member 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Matrix	Plasma Membrane Membrane
	Molecular Function	Protein Binding Galactose Binding Galactoside Binding Enzyme Binding Carbohydrate Binding Receptor Ligand Activity Disaccharide Binding Oligosaccharide Binding	G Protein-coupled Receptor Activity Olfactory Receptor Activity Identical Protein Binding
	Biological Process	Immune System Process Natural Killer Cell Tolerance Induction Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Female Pregnancy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Lipopolysaccharide Regulation Of Interleukin-4 Production Regulation Of Interleukin-5 Production Negative Regulation Of Chemokine Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway P38MAPK Cascade Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Activated T Cell Proliferation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Maternal Process Involved In Female Pregnancy Positive Regulation Of Activated T Cell Autonomous Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Type II Interferon Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Monocyte Chemotactic Protein-1 Production Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Single Fertilization Sensory Perception Of Smell Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell
Pathways		Interleukin-2 family signaling	Olfactory Signaling Pathway Olfactory Signaling Pathway Expression and translocation of olfactory receptors
Drugs		(R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol	None
GWAS		Blood protein levels ( 30072576 ) Crohn's disease ( 23128233 ) Irritable mood ( 29500382 )	Endometriosis ( 23472165 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Metabolite levels ( 23823483 )
Novel Interactors		2 novel interactors: CALCOCO2 OR1D2	1 novel interactors: LGALS9
Interacting Genes		6 interacting genes: CFTR DAZAP2 KRTAP6-3 P4HB PDIA6 RNF13	None recorded
Entrez ID		3965	4991
HPRD ID		03528	01255
Ensembl ID		ENSG00000168961	ENSG00000184166
Uniprot IDs		O00182	A0A126GVV4 P34982
PDB IDs		2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6	Not available
GO Terms Enriched among Interactors		Endoplasmic Reticulum Chaperone Complex Isomerase Activity Protein Disulfide Isomerase Activity Protein-disulfide Reductase Activity Response To Endoplasmic Reticulum Stress Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Anion Channel Activity Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Endoplasmic Reticulum-Golgi Intermediate Compartment Melanosome Procollagen-proline 4-dioxygenase Complex Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Peptidyl-proline Hydroxylation Endoplasmic Reticulum Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Interleukin-23-mediated Signaling Pathway Procollagen-proline 4-dioxygenase Activity Thiol Oxidase Activity Xenophagy Positive Regulation Of Autophagosome Maturation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Protein-containing Complex Amelogenesis Protein Folding Insulin Processing Interleukin-12-mediated Signaling Pathway ATPase-coupled Inorganic Anion Transmembrane Transporter Activity	Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Toll-like Receptor 2 Signaling Pathway Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Mature Conventional Dendritic Cell Differentiation Galactoside Binding Positive Regulation Of Activated T Cell Autonomous Cell Death Disaccharide Binding Positive Regulation Of Dendritic Cell Differentiation Galactose Binding Natural Killer Cell Tolerance Induction Positive Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Mast Cell Degranulation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Oligosaccharide Binding Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Interleukin-13 Production Negative Regulation Of Alpha-beta T Cell Proliferation Regulation Of Dendritic Cell Differentiation Positive Regulation Of Lymphocyte Apoptotic Process Tolerance Induction Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Alpha-beta T Cell Proliferation P38MAPK Cascade Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Viral Life Cycle Regulation Of Interleukin-5 Production Regulation Of Viral Entry Into Host Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Chemokine Production Regulation Of Mast Cell Degranulation Positive Regulation Of Leukocyte Apoptotic Process Regulation Of Activated T Cell Proliferation Dendritic Cell Differentiation Toll-like Receptor 4 Signaling Pathway Regulation Of P38MAPK Cascade Regulation Of Interleukin-4 Production Negative Regulation Of Exocytosis Negative Regulation Of Type II Interferon Production Maternal Process Involved In Female Pregnancy