LGALS9

Description		galectin 9
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Matrix
	Molecular Function	Protein Binding Galactose Binding Galactoside Binding Enzyme Binding Carbohydrate Binding Receptor Ligand Activity Disaccharide Binding Oligosaccharide Binding
	Biological Process	Immune System Process Natural Killer Cell Tolerance Induction Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Female Pregnancy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Lipopolysaccharide Regulation Of Interleukin-4 Production Regulation Of Interleukin-5 Production Negative Regulation Of Chemokine Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway P38MAPK Cascade Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Activated T Cell Proliferation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Maternal Process Involved In Female Pregnancy Positive Regulation Of Activated T Cell Autonomous Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Type II Interferon Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Monocyte Chemotactic Protein-1 Production Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation
Pathways		Interleukin-2 family signaling
Drugs		(R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol
Diseases
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 23128233) Irritable mood ( 29500382)
Novel Interacting Genes		2 novel interacting genes: CALCOCO2 OR1D2
Interacting Genes		6 interacting genes: CFTR DAZAP2 KRTAP6-3 P4HB PDIA6 RNF13
Entrez ID		3965
HPRD ID		03528
Ensembl ID		ENSG00000168961
Uniprot IDs		O00182
PDB IDs		2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Chaperone Complex Isomerase Activity Protein Disulfide Isomerase Activity Protein-disulfide Reductase Activity Response To Endoplasmic Reticulum Stress Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Anion Channel Activity Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Endoplasmic Reticulum-Golgi Intermediate Compartment Melanosome Procollagen-proline 4-dioxygenase Complex Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Peptidyl-proline Hydroxylation Endoplasmic Reticulum Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Interleukin-23-mediated Signaling Pathway Procollagen-proline 4-dioxygenase Activity Thiol Oxidase Activity Xenophagy Positive Regulation Of Autophagosome Maturation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Protein-containing Complex Amelogenesis Protein Folding Insulin Processing Interleukin-12-mediated Signaling Pathway ATPase-coupled Inorganic Anion Transmembrane Transporter Activity
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