TIMM10B and RPLP2

		TIMM10B	RPLP2
Description		translocase of inner mitochondrial membrane 10B	ribosomal protein lateral stalk subunit P2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Intermembrane Space Chaperone Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex	Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Metal Ion Binding Unfolded Protein Binding Protein Transporter Activity	Structural Constituent Of Ribosome Protein Binding
	Biological Process	Cell-matrix Adhesion Protein Transport Protein Insertion Into Mitochondrial Inner Membrane	Cytoplasmic Translation Cytoplasmic Translational Elongation Translation Translational Elongation
Pathways		Mitochondrial protein import	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
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Diseases
GWAS		Malaria ( 31844061)	Intraocular pressure ( 29785010) Keratoconus ( 33649486)
Interacting Genes		5 interacting genes: EIF3F HGS KLHL38 MBD3 MEIS2	8 interacting genes: GRK2 LINC00839 MAPK8 PTEN RPLP1 SRPK2 WEE2-AS1 YWHAQ
Entrez ID		26515	6181
HPRD ID		16242	01612
Ensembl ID		ENSG00000132286	ENSG00000177600
Uniprot IDs		B2R4A9 Q9Y5J6	P05387
PDB IDs		7CGP	1S4J 2JDL 2LBF 2W1O 4BEH 4V6X 5DDZ 5GU4
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Relaxation Of Smooth Muscle Edg-2 Lysophosphatidic Acid Receptor Binding Protein Serine/threonine Kinase Activity Synapse Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Peptidyl-serine Phosphorylation Intracellular Signaling Cassette JUN Phosphorylation Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity 14-3-3 Protein Binding
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