KRT39 and KRT74

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT39	KRT74
Description		keratin 39	keratin 74
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Intermediate Filament Keratin Filament	Cytoplasm Cytosol Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization	Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases			Woolly hair, including: Autosomal-dominant woolly hair (ADWH); Autosomal-recessive woolly hair (ARWH); Autosomal-recessive woolly hair with or without hypotrichosis
GWAS			Venous thromboembolism ( 32232851)
Interacting Genes		34 interacting genes: ANKS1A ARMC7 BEX2 C1orf216 CCDC196 CLCNKA FAM110A GFAP HGS IGFN1 KDM1A KLHL38 KRT1 KRT2 KRT3 KRT6B KRT74 KRT76 KRT78 KRT81 KRT83 KRT85 KRT86 LMO4 PPL PRPF18 SCNM1 SHC3 SMARCE1 TGM7 TXLNB UBASH3A VPS9D1 ZNF417	18 interacting genes: KRT13 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 LMO4
Entrez ID		390792	121391
HPRD ID		13750	10504
Ensembl ID		ENSG00000196859	ENSG00000170484
Uniprot IDs		Q6A163	Q7RTS7
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratinization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Supramolecular Fiber Organization Cytoskeleton Organization Epidermis Development Organelle Organization Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Peptide Cross-linking	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Supramolecular Fiber Organization Epithelial Cell Differentiation Tissue Morphogenesis Cytoskeleton Organization Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Organelle Organization Cellular Developmental Process Extracellular Exosome Developmental Process Cytosol Hair Cycle Structural Constituent Of Cytoskeleton Epidermis Development Hair Follicle Morphogenesis Tissue Development Intermediate Filament Cytoskeleton Keratinization Terminal Web Ventral Spinal Cord Interneuron Differentiation Hair Cycle Process Keratinocyte Migration Spinal Cord Motor Neuron Cell Fate Specification
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