KTN1 and SYNPR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KTN1	SYNPR
Description		kinectin 1	synaptoporin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse
	Molecular Function	RNA Binding Protein Binding Kinesin Binding Cadherin Binding	Protein Binding
	Biological Process	Microtubule-based Movement Protein Transport
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Early spontaneous preterm birth ( 31194736) Lean body mass ( 28552196) Neurofibrillary tangles ( 31497858) Plasma anti-thyroglobulin levels ( 29678681) Subcortical brain region volumes ( 25607358)	Autism ( 30675382) Congenital heart disease (inherited effect) ( 28468790) Congenital left-sided heart lesions ( 25138779) Idiopathic downbeat nystagmus ( 32157568) Lean body mass ( 28552196) Major depressive disorder ( 29317602)
Interacting Genes		31 interacting genes: ABI1 BNIP3 CD3G CD68 CDC42 CLEC4C CLEC7A EEF1D FFAR2 FILNC1 IKBKE KIF5B KIR2DL3 LHFPL5 M6PR MEOX2 PDCD1LG2 PLEKHA5 RAC1 RHOA RHOG RNF10 SGTA SIRPA SLC71A2 STOM SUSD3 SYNE4 SYNPR TMEM179B UBE2I	11 interacting genes: ARLN CREB3 DOLK FATE1 GALNT15 GPR37L1 KTN1 PLPP6 SLC1A1 SMCO4 TRARG1
Entrez ID		3895	132204
HPRD ID		02661	15458
Ensembl ID		ENSG00000126777	ENSG00000163630
Uniprot IDs		Q86UP2	Q8TBG9
PDB IDs
Enriched GO Terms of Interacting Partners?		Ficolin-1-rich Granule Membrane Establishment Or Maintenance Of Cell Polarity Secretory Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Membrane Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Glutamatergic Synapse G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Immune System Process Membrane Invagination Actin Filament Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway Azurophil Granule Membrane Thioesterase Binding Regulation Of Interleukin-23 Production Regulation Of Synapse Organization Positive Regulation Of Actin Filament Bundle Assembly Immune Response Tertiary Granule Membrane Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Antifungal Innate Immune Response G Protein Activity Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Cellular Response To Type II Interferon Positive Regulation Of Immune System Process Regulation Of Immune System Process Response To External Biotic Stimulus Positive Regulation Of Protein Localization To Membrane Regulation Of Respiratory Burst Regulation Of Modification Of Synaptic Structure Establishment Of Cell Polarity GTP-dependent Protein Binding Regulation Of Stress Fiber Assembly Regulation Of Cell Maturation Postsynapse Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Type II Interferon Regulation Of Chemokine Production Rac Protein Signal Transduction	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum D-aspartate Transmembrane Transporter Activity Positive Regulation Of Deacetylase Activity Dolichol Kinase Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Response To Anesthetic Conditioned Place Preference D-aspartate Import Across Plasma Membrane Cysteine Transmembrane Transport Intracellular Glutamate Homeostasis Vesicle-mediated Transport To The Plasma Membrane Cysteine Transport High-affinity L-glutamate Transmembrane Transporter Activity D-aspartate Transmembrane Transport Cysteine Transmembrane Transporter Activity Response To Ammonium Ion Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Distal Dendrite Glutamate:sodium Symporter Activity Response To Bisphenol A Perisynaptic Space L-aspartate Import Across Plasma Membrane Cellular Response To Bisphenol A Prosaposin Receptor Activity Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation CCR1 Chemokine Receptor Binding Release From Viral Latency Terpenoid Metabolic Process Isoprenoid Metabolic Process Dolichol Phosphate Mannose Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Negative Regulation Of Mitochondrial Calcium Ion Concentration Glucose Import In Response To Insulin Stimulus Lipid Phosphatase Activity Farnesyl Diphosphate Metabolic Process Geranyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Positive Regulation Of Neutrophil Activation
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