KRT86 and CDK18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT86	CDK18
Description		keratin 86	cyclin dependent kinase 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Intermediate Filament Keratin Filament	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Keratinization Intermediate Filament Organization	Positive Regulation Of Myelination Regulation Of Cell Cycle Phase Transition
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases		Monilethrix
GWAS		Blond vs. brown/black hair color ( 30531825) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)	Coronary artery disease in type 1 diabetes ( 29695241)
Interacting Genes		45 interacting genes: CAMK2B CCDC146 CDK18 CEP57 CREB5 CYSRT1 GNE HGS HSD3B7 IL16 JOSD1 KANK2 KRT14 KRT15 KRT16 KRT19 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT76 MAPKBP1 MEOX2 MGAT5B MKRN3 NUTF2 ODF1 OIP5 OLIG3 RESF1 RTP5 SHC3 TEKT4 TSGA10IP ZNF414 ZNF655	55 interacting genes: AK8 APP BLZF1 CBY2 CCDC102B CCDC125 CCDC85B CCDC88B CCND3 CCNDBP1 CCNK CEP76 EYA2 FSD2 GOLGA2 GOLGA6L9 GORASP2 HAP1 HMBOX1 HOMER3 HOOK2 INCA1 KIFC3 KRT15 KRT16 KRT31 KRT34 KRT40 KRT75 KRT86 LZTS2 MAD1L1 MID2 MIPOL1 MTUS2 NUTM1 PIBF1 PNMA1 PPFIA1 RABEP1 REL SEC23A TRAF1 TRAF2 TRIM27 TRIM50 TRIM54 TSGA10 TTC23 VPS28 VPS52 ZNF426 ZNF438 ZNF774 ZRANB1
Entrez ID		3892	5129
HPRD ID		03567	01354
Ensembl ID		ENSG00000170442	ENSG00000117266
Uniprot IDs		A8K872 O43790	Q07002 Q59G02
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Supramolecular Fiber Organization Cytoskeleton Cytoskeleton Organization Epidermis Development Anatomical Structure Morphogenesis Hair Cycle Organelle Organization Cell Differentiation Extracellular Exosome Cellular Developmental Process Structural Constituent Of Cytoskeleton Tissue Development Protein Binding Developmental Process Hair Follicle Morphogenesis Cytosol Cornified Envelope Hair Cycle Process	Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Centrosome Microtubule Protein Binding Microtubule Binding Cytoplasm Structural Molecule Activity Organelle Organization Microtubule-based Process Dynein Light Intermediate Chain Binding Identical Protein Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Cytosol Cellular Localization Thioesterase Binding Cis-Golgi Network Golgi Organization Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
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