KRT86 and JOSD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT86	JOSD1
Description		keratin 86	Josephin domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Intermediate Filament Keratin Filament	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	Keratinization Intermediate Filament Organization	Proteolysis Endocytosis Protein Deubiquitination Membrane Biogenesis Cell Motility Membrane Organization
Pathways		Keratinization Formation of the cornified envelope	Josephin domain DUBs
Drugs
Diseases		Monilethrix
GWAS		Blond vs. brown/black hair color ( 30531825) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Plateletcrit ( 32888494) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		45 interacting genes: CAMK2B CCDC146 CDK18 CEP57 CREB5 CYSRT1 GNE HGS HSD3B7 IL16 JOSD1 KANK2 KRT14 KRT15 KRT16 KRT19 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT76 MAPKBP1 MEOX2 MGAT5B MKRN3 NUTF2 ODF1 OIP5 OLIG3 RESF1 RTP5 SHC3 TEKT4 TSGA10IP ZNF414 ZNF655	38 interacting genes: ADAMTSL4 CARD10 CYSRT1 FBLN2 KRT27 KRT31 KRT34 KRT40 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 KRTAP9-2 KRTAP9-3 LNX1 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PJA1 STUB1 TGM1 TRAF1 TRIM23 TRIM27 TRIM54 TRIM63 UBC USP15 USP21 USP28
Entrez ID		3892	9929
HPRD ID		03567	08823
Ensembl ID		ENSG00000170442	ENSG00000100221
Uniprot IDs		A8K872 O43790	Q15040
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Supramolecular Fiber Organization Cytoskeleton Cytoskeleton Organization Epidermis Development Anatomical Structure Morphogenesis Hair Cycle Organelle Organization Cell Differentiation Extracellular Exosome Cellular Developmental Process Structural Constituent Of Cytoskeleton Tissue Development Protein Binding Developmental Process Hair Follicle Morphogenesis Cytosol Cornified Envelope Hair Cycle Process	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Identical Protein Binding Intermediate Filament Organization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Protein Modification Process Ubiquitin-protein Transferase Activity Epidermis Development Negative Regulation Of Viral Transcription Positive Regulation Of Autophagy Suppression Of Viral Release By Host Structural Molecule Activity Supramolecular Fiber Organization Regulation Of Viral Transcription Microtubule Cysteine-type Deubiquitinase Activity Protein Deubiquitination Deubiquitinase Activity
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