VGLL3 and PLA2G10

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VGLL3	PLA2G10
Name		vestigial like family member 3	phospholipase A2 group X
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle
	Molecular Function	Protein Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Axon Guidance Fertilization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonate Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Hair Follicle Morphogenesis Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Intestinal Stem Cell Homeostasis Macrophage Activation Cholesterol Homeostasis Regulation Of Macrophage Activation Erythrocyte Maturation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonate Secretion Negative Regulation Of Cholesterol Efflux Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Acrosome Reaction
Pathways		None	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs		None	Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
GWAS		Adventurousness ( 30643258 ) Breast cancer ( 29059683 ) General risk tolerance (MTAG) ( 30643258 ) HDL cholesterol levels ( 32203549 ) Hip index ( 34021172 ) Menarche (age at onset) ( 27182965 21102462 ) Metabolite levels ( 23823483 ) Molybdenum levels ( 26025379 ) Number of sexual partners ( 30643258 ) Obesity-related traits ( 23251661 ) Prostate cancer ( 26443449 31562322 ) Pubertal anthropometrics ( 23449627 ) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Smoking status (ever vs never smokers) ( 30643258 ) Triglyceride levels ( 32203549 )	Cholesteryl ester levels ( 31551469 )
Novel Interactors		None recorded	1 novel interactors: GRIN2A
Interacting Genes		65 interacting genes: CDPF1 CERCAM CNFN CTRC CYSRT1 DTX2 ESM1 FAM168B FRS3 HGS INCA1 KPRP KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-11 KRTAP4-2 KRTAP5-11 KRTAP5-6 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LASP1 LENG8 MDFI MYO15B OXER1 PCSK5 PITX1 PITX2 PLA2G10 POGZ POU2AF1 PRR22 RBPMS RUSC1 SMARCC1 SMOC1 SPMIP9 TBX15 TEAD1 TEAD2 TEAD3 TEAD4 TRIM42 TSC1 TSPAN4 UFSP1 YPEL3 ZNF34	55 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXA1 HOXC8 HR HSF4 INCA1 KPRP KRTAP10-8 KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE1F LCE2A LCE2B LCE2D LCE3A LCE5A MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 PLSCR4 POU4F3 ROR2 SAXO4 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10
Entrez ID		389136	8399
HPRD ID		13431	04674
Ensembl ID		ENSG00000206538	ENSG00000069764
Uniprot IDs		A8MV65	O15496
PDB IDs		Not available	1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Hippo Signaling Embryonic Organ Development TEAD-YAP Complex Protein Binding Transcription Regulator Complex	Keratinization Epidermis Development Tissue Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Protein Binding Chromatin