KRT81 and KRT18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT81	KRT18
Description		keratin 81	keratin 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Intermediate Filament Keratin Filament	Nucleus Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Intermediate Filament Adherens Junction Nuclear Matrix Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	RNA Binding Structural Molecule Activity Protein Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Keratinization Intermediate Filament Organization	Anatomical Structure Morphogenesis Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Cell-cell Adhesion
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases		Monilethrix
GWAS		Diisocyanate-induced asthma ( 25918132)	Diffusing capacity of carbon monoxide ( 30694715) Nonsyndromic cleft lip with cleft palate ( 28232668)
Interacting Genes		30 interacting genes: CYSRT1 DMRTB1 HOXA1 KRT13 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KXD1 LCA5L MEOX2 OIP5 OTX1 PCBP3 SKIL	94 interacting genes: AIRIM BBS1 BBS2 BBS4 BBS7 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCHCR1 CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EFHC1 EGFR EP300 ESR1 EXOC8 FRAT1 FXR1 FXR2 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 HSPB1 IKBKG KIFC3 KPNA2 KRT15 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT8 KRT81 LDOC1 LINC01554 MAPK14 NEFL NME7 ORC5 PDE4B PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE PSTPIP2 RAF1 RCOR3 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SVIL SYCE1 TCHP TEKT4 TNFRSF1B TRADD TSG101 TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A WBP2 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		3887	3875
HPRD ID		03691	01020
Ensembl ID		ENSG00000205426	ENSG00000111057
Uniprot IDs		Q14533	P05783
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Epithelial Cell Differentiation Morphogenesis Of An Epithelium Tissue Morphogenesis Supramolecular Fiber Organization Cytoskeleton Organization Anatomical Structure Morphogenesis Cytoskeleton Extracellular Exosome Cell Differentiation Developmental Process Organelle Organization Cellular Developmental Process Hair Cycle Epidermis Development Structural Constituent Of Cytoskeleton Cytosol Hair Follicle Morphogenesis Tissue Development Cornified Envelope Hair Cycle Process Cell Periphery Protein Binding Semicircular Canal Formation Diencephalon Morphogenesis C-rich Single-stranded DNA Binding Establishment Of Skin Barrier Skin Epidermis Development Abducens Nerve Formation Optokinetic Behavior Intermediate Filament Cytoskeleton	Cytosol Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Cytoplasm Organelle Organization Cytoskeleton Organization Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Cytoskeleton Establishment Of Protein Localization Nucleus Developmental Process Supramolecular Fiber Organization BBSome Regulation Of Apoptotic Process Intracellular Protein Localization Protein Domain Specific Binding Regulation Of Programmed Cell Death Cellular Component Assembly Centrosome Regulation Of Protein Metabolic Process Keratinization Establishment Of Localization In Cell Reproductive Process Response To Lipid Enzyme Binding Apoptotic Process Protein Binding Regulation Of Cellular Component Organization Programmed Cell Death Cell Death Cellular Response To Staurosporine Ciliary Basal Body Cellular Localization Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Protein Localization Intracellular Signal Transduction Hippocampus Development Regulation Of Microtubule Nucleation Phosphoserine Residue Binding Focal Adhesion Pyroptotic Inflammatory Response Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Death-inducing Signaling Complex Desmosome Assembly
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