KLRC3 and TSPAN15

		KLRC3	TSPAN15
Description		killer cell lectin like receptor C3	tetraspanin 15
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Late Endosome Membrane Tetraspanin-enriched Microdomain
	Molecular Function	Transmembrane Signaling Receptor Activity Carbohydrate Binding	Protein Binding Enzyme Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Defense Response Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Protein Localization To Plasma Membrane
Pathways			Amyloid fiber formation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Mean corpuscular volume ( 27863252)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Response to taxane treatment (paclitaxel) ( 23006423) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombosis ( 26908601) Type 2 diabetes ( 32499647) Venous thromboembolism ( 25772935 28373160 31420334 31676865)
Interacting Genes		3 interacting genes: KLRD1 RHOU TYROBP	5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4
Entrez ID		3823	23555
HPRD ID		04203	15511
Ensembl ID		ENSG00000205810	ENSG00000099282
Uniprot IDs		Q07444	O95858
PDB IDs			7RD5 7RDB 8ESV
Enriched GO Terms of Interacting Partners?		Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity HLA-E Specific Inhibitory MHC Class Ib Receptor Activity MHC Class Ib Protein Binding, Via Antigen Binding Groove Leukocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Protein-macromolecule Adaptor Activity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Microglial Cell Activation Involved In Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Effector Process Negative Regulation Of Transforming Growth Factor Beta1 Production Immune Response-regulating Cell Surface Receptor Signaling Pathway MHC Class I Protein Complex Binding Positive Regulation Of Innate Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Focal Adhesion Disassembly Protein Antigen Binding Regulation Of Osteoclast Development Tetraspanin-enriched Microdomain Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response-activating Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Production Immune Effector Process Immune Response-regulating Signaling Pathway Actin Filament-based Process Activation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of B Cell Proliferation Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Protein Localization To Cell Surface Macrophage Activation Involved In Immune Response Positive Regulation Of Superoxide Anion Generation Plasma Membrane
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