KCND3 and KCNIP2

Number of citations of the paper that reports this interaction (PubMedID 12928444)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KCND3	KCNIP2
Description		potassium voltage-gated channel subfamily D member 3	potassium voltage-gated channel interacting protein 2
Image
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Monoatomic Ion Channel Complex Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Kv4.3-KChIP1 Channel Complex GABA-ergic Synapse Postsynaptic Specialization Membrane	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Monoatomic Ion Channel Complex Synapse Kv4.2-KChIP2 Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Protein Binding Metal Ion Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding ER Retention Sequence Binding
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Chemical Synaptic Transmission Regulation Of Heart Contraction Monoatomic Ion Transmembrane Transport Protein Homooligomerization Protein Tetramerization Transmembrane Transport Potassium Ion Transmembrane Transport Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization	Action Potential Detection Of Calcium Ion Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Regulation Of Heart Contraction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Clustering Of Voltage-gated Potassium Channels Regulation Of Membrane Repolarization Potassium Ion Transmembrane Transport Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Export Across Plasma Membrane
Pathways		Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels	Phase 1 - inactivation of fast Na+ channels
Drugs		Enflurane Disopyramide Imipramine Promethazine Miconazole Nifedipine Dronedarone Vernakalant Dalfampridine Isavuconazole
Diseases
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 33990960 28416822 29892015 30061737) Early cardiac repolarization ( 22683750 31600170) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Medication use (opioids) ( 31015401) Multisite chronic pain ( 31194737 33830993) P wave duration ( 24850809) P wave terminal force ( 28794112) PR interval ( 30679814 32439900) Response to radiotherapy in cancer (late toxicity) ( 24785509) TPE interval (resting) ( 32386560) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Visceral adipose tissue adjusted for BMI ( 22589738)	Raw vegetable consumption ( 32066663)
Interacting Genes		2 interacting genes: KCNIP1 KCNIP2	5 interacting genes: GOLGA7 KCND2 KCND3 KCNIP1 SYCE1L
Entrez ID		3752	30819
HPRD ID		16104	06880
Ensembl ID		ENSG00000171385	ENSG00000120049
Uniprot IDs		Q9UK17	A0A2R8Y6D7 B3KSZ5 Q9NS61
PDB IDs		1S1G 2NZ0 7W3Y 7W6N 7W6S 7W6T	7UKH 7W6S
Enriched GO Terms of Interacting Partners?		Membrane Repolarization Potassium Channel Regulator Activity Regulation Of Potassium Ion Transmembrane Transport Potassium Channel Activity Regulation Of Potassium Ion Transport Voltage-gated Potassium Channel Complex Monoatomic Ion Channel Complex Transmembrane Transporter Binding Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Heart Contraction Muscle Contraction Regulation Of Blood Circulation Muscle System Process Kv4.2-KChIP2 Channel Complex Regulation Of Monoatomic Cation Transmembrane Transport Kv4.3-KChIP1 Channel Complex Regulation Of Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Regulation Of Metal Ion Transport Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Potassium Ion Export Across Plasma Membrane Clustering Of Voltage-gated Potassium Channels A-type (transient Outward) Potassium Channel Activity ER Retention Sequence Binding Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Dendrite Regulation Of System Process Cell-cell Signaling Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Neuronal Ion Channel Clustering Calcium Ion Binding Signaling Regulation Of Potassium Ion Export Across Plasma Membrane Cell Communication Inorganic Ion Transmembrane Transport Detection Of Calcium Ion Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Monoatomic Ion Transport Synapse Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transport	Membrane Repolarization Kv4.3-KChIP1 Channel Complex A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Potassium Ion Transport Regulation Of Heart Contraction Muscle Contraction Regulation Of Blood Circulation Muscle System Process Postsynaptic Specialization Membrane Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Voltage-gated Potassium Channel Activity Export Across Plasma Membrane Regulation Of Membrane Potential Dendrite Regulation Of System Process GABA-ergic Synapse Cell-cell Signaling Action Potential Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Signaling Cell Communication Kv4.2-KChIP2 Channel Complex Inorganic Ion Transmembrane Transport Dendritic Spine Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Palmitoyltransferase Complex Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Protein Homooligomerization Monoatomic Ion Transport Postsynaptic Membrane Protein Complex Oligomerization Regulation Of Biological Quality Transmembrane Transport Peptidyl-L-cysteine S-palmitoylation Locomotor Rhythm Cell Projection Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization
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