KCND3

Description		potassium voltage-gated channel subfamily D member 3
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Monoatomic Ion Channel Complex Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Kv4.3-KChIP1 Channel Complex GABA-ergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Protein Binding Metal Ion Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Chemical Synaptic Transmission Regulation Of Heart Contraction Monoatomic Ion Transmembrane Transport Protein Homooligomerization Protein Tetramerization Transmembrane Transport Potassium Ion Transmembrane Transport Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization
Pathways		Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels
Drugs		Enflurane Disopyramide Imipramine Promethazine Miconazole Nifedipine Dronedarone Vernakalant Dalfampridine Isavuconazole
Diseases
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 33990960 28416822 29892015 30061737) Early cardiac repolarization ( 22683750 31600170) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Medication use (opioids) ( 31015401) Multisite chronic pain ( 31194737 33830993) P wave duration ( 24850809) P wave terminal force ( 28794112) PR interval ( 30679814 32439900) Response to radiotherapy in cancer (late toxicity) ( 24785509) TPE interval (resting) ( 32386560) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		2 interacting genes: KCNIP1 KCNIP2
Entrez ID		3752
HPRD ID		16104
Ensembl ID		ENSG00000171385
Uniprot IDs		Q9UK17
PDB IDs		1S1G 2NZ0 7W3Y 7W6N 7W6S 7W6T
Enriched GO Terms of Interacting Partners?		Membrane Repolarization Potassium Channel Regulator Activity Regulation Of Potassium Ion Transmembrane Transport Potassium Channel Activity Regulation Of Potassium Ion Transport Voltage-gated Potassium Channel Complex Monoatomic Ion Channel Complex Transmembrane Transporter Binding Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Heart Contraction Muscle Contraction Regulation Of Blood Circulation Muscle System Process Kv4.2-KChIP2 Channel Complex Regulation Of Monoatomic Cation Transmembrane Transport Kv4.3-KChIP1 Channel Complex Regulation Of Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Regulation Of Metal Ion Transport Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Potassium Ion Export Across Plasma Membrane Clustering Of Voltage-gated Potassium Channels A-type (transient Outward) Potassium Channel Activity ER Retention Sequence Binding Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Dendrite Regulation Of System Process Cell-cell Signaling Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Neuronal Ion Channel Clustering Calcium Ion Binding Signaling Regulation Of Potassium Ion Export Across Plasma Membrane Cell Communication Inorganic Ion Transmembrane Transport Detection Of Calcium Ion Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Monoatomic Ion Transport Synapse Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transport
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