KCNA6 and DOLK

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		KCNA6	DOLK
Name		potassium voltage-gated channel subfamily A member 6	dolichol kinase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Monoatomic Ion Channel Complex Potassium Channel Complex Axon Terminus	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding	Dolichol Kinase Activity Protein Binding Kinase Activity Transferase Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport	Protein N-linked Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Voltage gated Potassium channels	Synthesis of dolichyl-phosphate Defective DOLK causes DOLK-CDG
Drugs		Enflurane Promethazine Miconazole Dalfampridine	None
Diseases		None	Congenital disorders of glycosylation (CDG) type I
GWAS		Anti-saccade response ( 29064472 ) Physical activity (moderate intensity activity duration) ( 30531941 ) Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		1 interacting genes: DOLK	21 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR
Entrez ID		3742	22845
HPRD ID		08884	15525
Ensembl ID		ENSG00000151079	ENSG00000175283
Uniprot IDs		P17658	A0A0S2Z597 Q9UPQ8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Dolichol Kinase Activity Dolichol Phosphate Mannose Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Isoprenoid Biosynthetic Process Glycolipid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Glycolipid Biosynthetic Process Protein N-linked Glycosylation Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Phospholipid Metabolic Process	Membrane Delayed Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Regulation Of Response To Endoplasmic Reticulum Stress Protein Complex Oligomerization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway L-lysine:L-arginine Antiporter Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Collagen Catabolic Process Regulation Of Collagen Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway