AQP7 and CLCN7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AQP7	CLCN7
Description		aquaporin 7	chloride voltage-gated channel 7
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GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Lysosome Lysosomal Membrane Membrane Chloride Channel Complex
	Molecular Function	Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Channel Activity	Nucleotide Binding Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity Chloride:proton Antiporter Activity
	Biological Process	Water Transport Glycerol Transmembrane Transport Transmembrane Transport Urea Transmembrane Transport	Monoatomic Ion Transport Chloride Transport Response To PH Transepithelial Chloride Transport Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport
Pathways		Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins	Stimuli-sensing channels
Drugs
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Lung adenocarcinoma ( 28604730) Urinary albumin excretion ( 30220432)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: ABHD16A CLCN7 COMT MFSD6	16 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B
Entrez ID		364	1186
HPRD ID		04277	04103
Ensembl ID		ENSG00000165269	ENSG00000103249
Uniprot IDs		B7Z4U2 O14520 Q5T5M0 Q6P5T0	P51798
PDB IDs		6KXW 6N1G 6QZI 6QZJ 8AMW 8AMX 8C9H	7BXU 7CQ5 7CQ6 7CQ7 7JM7 8HVT
Enriched GO Terms of Interacting Partners?		Chloride:proton Antiporter Activity Cellular Response To Phosphate Starvation Norepinephrine Secretion Catechol O-methyltransferase Activity Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Transepithelial Chloride Transport O-methyltransferase Activity Renal Tubular Secretion Dopamine Secretion Habituation Renal Protein Absorption Mastication Catecholamine Catabolic Process Renal Sodium Excretion Renal Albumin Absorption Norepinephrine Transport Nonassociative Learning Renin Secretion Into Blood Stream Cellular Response To Cocaine Response To Dopamine Dopamine Catabolic Process Catecholamine Secretion Cerebellar Cortex Morphogenesis Monoacylglycerol Catabolic Process Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Monoacylglycerol Lipase Activity Synaptic Transmission, Dopaminergic Glomerulus Development Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Norepinephrine Metabolic Process Startle Response Response To Corticosterone Phosphatidylserine Metabolic Process Chloride Transmembrane Transporter Activity Renal Filtration Dopamine Transport Response To Catecholamine Detection Of Temperature Stimulus Involved In Sensory Perception Phosphatidylcholine Lysophospholipase Activity Detection Of Temperature Stimulus Response To Salt Glycerophospholipid Catabolic Process Response To Angiotensin Phospholipase Activity Acylglycerol Catabolic Process Cholesterol Efflux Monoamine Transport Dopamine Metabolic Process	Membrane Protein-membrane Adaptor Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Deacetylase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Monoatomic Ion Transport
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