IRF2BP2 and NFATC2

Number of citations of the paper that reports this interaction (PMID 21576369)
3

Data Source:
BioGRID (pull down)

		IRF2BP2	NFATC2
Gene Name		interferon regulatory factor 2 binding protein 2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Ribonucleoprotein Complex Nuclear Transcription Factor Complex
	Molecular Function	Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cytokine Production Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Cell Migration Positive Regulation Of B Cell Proliferation Fc-epsilon Receptor Signaling Pathway Response To Drug Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter B Cell Receptor Signaling Pathway
Pathways			Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System
Drugs
Diseases
GWAS		Bipolar disorder ( 22688191) Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Life threatening arrhythmia ( 22247754)
Protein-Protein Interactions		2 interactors: IRF2 NFATC2	19 interactors: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 JUN MED31 MEF2D NFATC2IP PIN1 PPP3CB PPP3R1 PRKCZ TAF9 VIM YWHAQ YWHAZ
Entrez ID		359948	4773
HPRD ID		17160	02730
Ensembl ID		ENSG00000168264	ENSG00000101096
Uniprot IDs		Q7Z5L9	B5B2P0 B5B2P2 B5B2P3 B5B2P4 Q13469
PDB IDs			1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Immune Response Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Defense Response B Cell Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Positive Regulation Of B Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of B Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of B Cell Activation Negative Regulation Of Cellular Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Transcription, DNA-templated Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation RNA Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Antigen Receptor-mediated Signaling Pathway Cytokine Production Positive Regulation Of Cellular Metabolic Process Cellular Response To Interferon-gamma Response To Interferon-gamma Cell Surface Receptor Signaling Pathway RNA Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Gene Expression Fc Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Macromolecule Biosynthetic Process Positive Regulation Of Cell Activation	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Immune Response Regulation Of Metabolic Process Defense Response Innate Immune Response Positive Regulation Of Interleukin-4 Production Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Signaling Cell Activation Regulation Of Interleukin-4 Production Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Leukocyte Activation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Regulation Of Signal Transduction Gene Expression Regulation Of CD4-positive, Alpha-beta T Cell Differentiation N-terminal Peptidyl-lysine Acetylation Histone Acetylation Regulation Of Cellular Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Cytokine Production Internal Protein Amino Acid Acetylation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Acetylation Leukocyte Differentiation Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Apoptotic Process Apoptotic Signaling Pathway T Cell Differentiation Positive Regulation Of Cytokine Production RNA Metabolic Process Regulation Of Apoptotic Process
Tagcloud ?		apl arsenic breakpoints consolidation cytogenetics ecchymoses epistaxis exon expands fusion gemtuzumab immunophenotypic intron list morphologic next oligonucleotide ozogamicin partners pml presents promyelocytic rara rarely relapsed remission sequencing translocations woman	calcineurin deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf
Tagcloud (Difference) ?		apl arsenic breakpoints consolidation cytogenetics ecchymoses epistaxis exon expands fusion gemtuzumab immunophenotypic intron list morphologic next oligonucleotide ozogamicin partners pml presents promyelocytic rara rarely relapsed remission sequencing translocations woman	calcineurin deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf
Tagcloud (Intersection) ?