IRF2BP2

Description		interferon regulatory factor 2 binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Corepressor Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immature B Cell Differentiation Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 22688191) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 20686565 24097068 25961943) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) LDL cholesterol ( 20686565 25961943 24097068) LDL cholesterol levels ( 28334899 32203549) Life threatening arrhythmia ( 22247754) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Spleen volume ( 34128465) Total cholesterol levels ( 28334899) White blood cell count (eosinophil) ( 28158719)
Interacting Genes		8 interacting genes: CEBPA ERBB2 ERBB3 ERBB4 IRF2 MAILR MTNR1B NFATC2
Entrez ID		359948
HPRD ID		17160
Ensembl ID		ENSG00000168264
Uniprot IDs		Q7Z5L9
PDB IDs		8YTF 8YTG 8YTH
Enriched GO Terms of Interacting Partners?		ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Transcription Cis-regulatory Region Binding ERBB Signaling Pathway Animal Organ Development ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Protein Tyrosine Kinase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Peripheral Nervous System Development Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Basolateral Plasma Membrane Growth Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Heart Development Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Protein Localization To Synapse Glial Cell Development Negative Regulation Of Apoptotic Process Cell Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Heterodimerization Activity Neuron Differentiation Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Negative Regulation Of Programmed Cell Death Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Multicellular Organismal Process Wound Healing
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