LCE3A and KRTAP5-8

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LCE3A	KRTAP5-8
Description		late cornified envelope 3A	keratin associated protein 5-8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytosol Intermediate Filament
	Molecular Function	Protein Binding	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Epidermis Development Keratinization Killing Of Cells Of Another Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Formation of the cornified envelope	Keratinization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23727859) Inflammatory skin disease ( 25574825) Psoriasis ( 19169255) Psoriasis vulgaris ( 26626624)
Interacting Genes		74 interacting genes: ADAMTSL4 ALPP CHIC2 CRCT1 CYSRT1 EFEMP1 EFEMP2 FBLN1 HOXA1 KPRP KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1C LCE2A LCE2B LCE2C LCE2D LCE3B LCE4A MACO1 MDFI NBPF19 NOTCH2NLA OIT3 PCSK5 PLA2G10 PLSCR2 RGS17 RGS20 SMCP SPRY1 SPRY3 TGFB1 TGM1 TRIM42 TSPAN4 VASN VWC2 VWC2L	6 interacting genes: CRCT1 HHEX LCE1E LCE3A LCE5A WNT11
Entrez ID		353142	57830
HPRD ID		13973	17252
Ensembl ID		ENSG00000185962	ENSG00000241233
Uniprot IDs		Q5TA76	O75690
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Protein Binding Cytosol Tissue Development Elastic Fiber Identical Protein Binding Interstitial Matrix	Keratinization Epidermis Development Tissue Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of MRNA Export From Nucleus Negative Regulation Of Cytoplasmic Translational Initiation Eukaryotic Initiation Factor 4E Binding Regionalization Secondary Palate Development Notochord Morphogenesis Nephron Tubule Morphogenesis Convergent Extension Involved In Axis Elongation Lung-associated Mesenchyme Development Negative Regulation Of Fibroblast Growth Factor Production Maintenance Of Epithelial Cell Apical/basal Polarity Primary Heart Field Specification Ureteric Bud Morphogenesis Wnt Signaling Pathway, Calcium Modulating Pathway Convergent Extension Cloacal Septation Positive Regulation Of Transforming Growth Factor Beta2 Production Atrial Septum Development Nephric Duct Development Regulation Of Transforming Growth Factor Beta2 Production Heart Field Specification Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Paraxial Mesoderm Formation Secondary Heart Field Specification Maintenance Of Cell Polarity Regulation Of Wnt Signaling Pathway DNA Binding, Bending Somite Development Regulation Of RNA Export From Nucleus Translation Regulator Activity DNA Conformation Change Specification Of Animal Organ Identity Renal Tubule Morphogenesis Neuroendocrine Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta Production Pattern Specification Process Positive Regulation Of Epithelial Cell Apoptotic Process Adrenal Gland Development TBP-class Protein Binding Mesenchymal Cell Proliferation
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