IGFBP1

Description		insulin like growth factor binding protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Growth Response To Insulin Tissue Regeneration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 28135244 30487518) Rheumatoid arthritis ( 21156761) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27618447)
Interacting Genes		4 interacting genes: IGF1 IGF2 MMP26 TF
Entrez ID		3484
HPRD ID		00897
Ensembl ID		ENSG00000146678
Uniprot IDs		P08833
PDB IDs		1ZT3 1ZT5 2DSQ
Enriched GO Terms of Interacting Partners?		Exocrine Pancreas Development Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Binding Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Glycogen Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Extracellular Space Platelet Alpha Granule Lumen Striated Muscle Cell Differentiation Insulin Receptor Signaling Pathway Regulation Of Organ Growth Regulation Of Glucose Metabolic Process Positive Regulation Of T Cell Proliferation Muscle Cell Differentiation Negative Regulation Of Oocyte Development Extracellular Region Hormone Activity Regulation Of Mitotic Nuclear Division Receptor Ligand Activity Osteoblast Differentiation Regulation Of Generation Of Precursor Metabolites And Energy Integrin Binding Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Trophectodermal Cell Proliferation Growth Factor Activity Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Nuclear Division Regulation Of Muscle Cell Differentiation Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Developmental Growth Positive Regulation Of Leukocyte Proliferation Regulation Of T Cell Proliferation Insulin-like Growth Factor Binding Protein Complex Glycolate Metabolic Process Negative Regulation Of Inflammatory Response Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Alphav-beta3 Integrin-IGF-1-IGF1R Complex Prostate Gland Stromal Morphogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Type B Pancreatic Cell Proliferation
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