C1QTNF9 and CAPN3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		C1QTNF9	CAPN3
Description		C1q and TNF related 9	calpain 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein-containing Complex
	Molecular Function	Hormone Activity Protein Binding Identical Protein Binding	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Hydrolase Activity Sodium Ion Binding Titin Binding Identical Protein Binding Metal Ion Binding Ligase Regulator Activity Molecular Adaptor Activity
	Biological Process	Signal Transduction	Proteolysis Apoptotic Process Muscle Organ Development Programmed Cell Death Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Protein Catabolic Process Myofibril Assembly Protein Destabilization Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Muscle Cell Cellular Homeostasis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development Protein-containing Complex Assembly G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis Calcium-dependent Self Proteolysis
Pathways			Degradation of the extracellular matrix
Drugs			L-aminocarnityl-succinyl-leucyl-argininal-diethylacetal
Diseases			Limb-girdle muscular dystrophy (LGMD) Calpainopathy; Limb-girdle muscular dystrophy 2A (LGMD2A)
GWAS			Fibrinogen levels ( 26561523 28107422) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Triglyceride levels ( 30698716 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 25961943 24097068 20686565)
Interacting Genes		17 interacting genes: ACTC1 AMPD1 APPL1 CAPN3 DENND4A DST EIF4G2 GYG1 LARP4B MYBPC1 MYOM1 NAP1L1 NDUFS1 RDX TTN UTRN ZNF407	32 interacting genes: AMOT C1QTNF9 CCDC102B CEP76 CMYA5 CRYAB DYSF EXOC8 FLNC FNDC3B FXR1 GTPBP3 KANK2 MAP1LC3C MMP2 MYBPC1 MYBPH NECAB2 NTAQ1 OSGIN1 POMP PREPL PSMC3 PSMD1 RNF167 RUFY3 TFCP2 TRIM55 TRIM63 TTN UBE3A YWHAQ
Entrez ID		338872	825
HPRD ID		14659	00255
Ensembl ID		ENSG00000240654	ENSG00000092529
Uniprot IDs		P0C862	A0A0S2Z3E1 P20807
PDB IDs			4OKH 6BDT 6BGP 6BJD 6BKJ
Enriched GO Terms of Interacting Partners?		Actomyosin Structure Organization Structural Constituent Of Muscle Sarcomere Organization Protein Kinase A Signaling M Band Myofibril Assembly Skeletal Muscle Thin Filament Assembly Actin Cytoskeleton Organization Actin Filament-based Process Filopodium Titin Binding Cardiac Myofibril Assembly Actin-myosin Filament Sliding Actin Cytoskeleton Myosin Filament Muscle Organ Development Cytoskeleton Organization I Band Myosin Binding Z Disc Muscle Structure Development Actin Binding Protein Homodimerization Activity Actin-mediated Cell Contraction Structural Molecule Activity Positive Regulation Of Gene Expression Muscle Contraction Cardiac Muscle Contraction Cytosol Calcium-dependent Self Proteolysis Positive Regulation Of Transport Myofibril T-tubule Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Sarcomere Muscle System Process Actin Filament-based Movement Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process H Zone Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Glycogenin Glucosyltransferase Activity Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Positive Regulation Of Macropinocytosis Cytoskeletal Protein Binding Positive Regulation Of Biosynthetic Process Muscle Tissue Morphogenesis	M Band Sarcomere Organization Cytoplasm Actomyosin Structure Organization Structural Constituent Of Muscle Z Disc Endomembrane System Contractile Muscle Fiber Titin Binding Proteasome Regulatory Particle, Base Subcomplex Proteasome Complex Cytoskeletal Protein Binding Costamere Proteasome Accessory Complex Actin Cytoskeleton Organization
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