KRTAP13-2 and HR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP13-2	HR
Description		keratin associated protein 13-2	HR lysine demethylase and nuclear receptor corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Structural Molecule Activity Protein Binding	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Histone H3K9me/H3K9me2 Demethylase Activity
	Biological Process		Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		Keratinization
Drugs
Diseases			Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH) Atrichia with papular lesions
GWAS			Obesity-related traits ( 23251661)
Interacting Genes		81 interacting genes: ANAPC11 ANXA11 BCL6 C22orf39 CBFA2T2 CCDC125 CCDC24 CCDC57 CCNK CFAP68 CRYBA1 CSKMT CYSRT1 ENKD1 EPDR1 ETFDH FANCL FBXO17 FCHO1 GATA3 GEMIN4 GNE GPS2 GRN HNRNPH1 HOXA1 HR KCTD9 KLHL38 KPRP KRT3 KRTAP1-1 KRTAP10-5 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-4 KRTAP4-5 KRTAP9-2 MAGOHB MEOX2 MGAT5B NBPF19 NEK8 NHLRC4 NOTCH2NLA OIP5 OTX1 P4HB PATZ1 PHETA1 PITX1 POU2AF1 RECK RHOXF2 SAXO4 SLC25A18 SLIT1 SMUG1 SNRPC SPEF1 SPMIP9 SSC4D STK16 TCAF1 TLE5 TNS2 TRAPPC6A TRIM68 TSPYL6 TSSK3 UNC5CL VGLL3 VWC2 YPEL3 ZIC1	35 interacting genes: ACTMAP AMMECR1 ATP23 CFAP68 CNFN CYSRT1 FAM168A GEMIN4 HDAC1 HDAC3 HDAC5 HMGB1 HOXA1 INCA1 KLHL20 KRTAP11-1 KRTAP13-2 KRTAP15-1 KRTAP3-1 KRTAP3-3 KRTAP6-3 MGAT5B PLA2G10 PRKCA RARA RARB RBP3 SPAG8 SPRY3 TBL1X TRIM27 TSC1 VDR YPEL3 ZMYND12
Entrez ID		337959	55806
HPRD ID		11201	03808
Ensembl ID		ENSG00000182816	ENSG00000168453
Uniprot IDs		Q52LG2	O43593
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding	Histone Deacetylase Activity, Hydrolytic Mechanism Intermediate Filament Histone Deacetylase Complex Protein Lysine Deacetylase Activity Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Transcription Repressor Complex Protein Lysine Delactylase Activity Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Glandular Epithelial Cell Development Keratin Filament Cardiac Muscle Cell Differentiation Negative Regulation Of Cytokine Production Ventricular Cardiac Muscle Cell Differentiation Nuclear Receptor-mediated Signaling Pathway Heterocyclic Compound Binding Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Cardiocyte Differentiation Transcription Corepressor Binding Histone Deacetylase Binding Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Growth Plate Cartilage Development Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Protein Deacetylation Positive Regulation Of RNA Biosynthetic Process Hippocampus Development Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription Striated Muscle Cell Differentiation Columnar/cuboidal Epithelial Cell Development Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Structural Molecule Activity Nuclear Retinoid X Receptor Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Regulation Of Striated Muscle Cell Differentiation Apoptotic Cell Clearance
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