KRTAP11-1 and PLA2G10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP11-1	PLA2G10
Description		keratin associated protein 11-1	phospholipase A2 group X
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle
	Molecular Function	Structural Molecule Activity Protein Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Axon Guidance Fertilization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonate Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Hair Follicle Morphogenesis Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Intestinal Stem Cell Homeostasis Macrophage Activation Cholesterol Homeostasis Regulation Of Macrophage Activation Erythrocyte Maturation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonate Secretion Negative Regulation Of Cholesterol Efflux Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Acrosome Reaction
Pathways		Keratinization	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs			Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Height ( 28552196)	Cholesteryl ester levels ( 31551469)
Interacting Genes		105 interacting genes: AGR3 ANAPC11 ANKS1A ASB13 ATG9A ATXN1L BEX2 CERK CFP CHERP CRYBA1 CRYBA2 CSKMT CYSRT1 DHRS1 DTX2 DUSP21 EFEMP2 ENKD1 ETFDH FAM222B FANCL FASLG FBLN1 FNDC3B FOXH1 FRS3 GATA2 GNE GPS2 GPSM3 GRN HEY2 HOXA1 HOXC8 HR KLHL38 KRT83 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP4-11 KRTAP4-2 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1F LCE2A LCE2B LCE3A LCE3C LGALS4 LIMS3 LIMS4 LMO4 MEIS2 MICOS10-NBL1 NBL1 NUFIP2 OIT3 OLIG3 OR7A17 OTX1 PCSK5 PLA2G10 PLSCR3 RBPMS RBPMS2 RNF38 SLC13A5 SNRPC SPAG8 SPRY1 STK16 TBX6 TEKT4 TENT5D TFAP2D TLE5 TLX3 TNS2 TRIM54 VASN VENTX VGLL3 VWC2L WWOX YIPF3 ZDHHC17 ZIC1	55 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXA1 HOXC8 HR HSF4 INCA1 KPRP KRTAP10-8 KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE1F LCE2A LCE2B LCE2D LCE3A LCE5A MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 PLSCR4 POU4F3 ROR2 SAXO4 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10
Entrez ID		337880	8399
HPRD ID		11196	04674
Ensembl ID		ENSG00000182591	ENSG00000069764
Uniprot IDs		Q8IUC1	O15496
PDB IDs			1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization Keratin Filament Protein Binding Epidermis Development Identical Protein Binding Tissue Development Hair Cycle Ventral Spinal Cord Interneuron Differentiation Regulation Of Neuron Differentiation Pattern Specification Process Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Developmental Process Elastic Fiber Determination Of Dorsal Identity Axonemal A Tubule Inner Sheath	Keratinization Epidermis Development Tissue Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Protein Binding Chromatin
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