HMGXB3 and NDST1

Data Source: HiPPIP (Novel)

		HMGXB3	NDST1
Name		HMG-box containing 3	N-deacetylase and N-sulfotransferase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Golgi Membrane Golgi Apparatus Membrane Trans-Golgi Network Membrane
	Molecular Function	DNA Binding	Catalytic Activity Protein Binding Sulfotransferase Activity Heparan Sulfate N-sulfotransferase Activity Transferase Activity Hydrolase Activity Deacetylase Activity N-acetylglucosamine Deacetylase Activity Heparan Sulfate N-deacetylase Activity
	Biological Process	Biological_process	Polysaccharide Biosynthetic Process Cardiac Septum Development Inflammatory Response Heart Development Respiratory Gaseous Exchange By Respiratory System Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process Forebrain Development Midbrain Development Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Coronary Vasculature Development
Pathways		None	HS-GAG biosynthesis
Drugs		None	Adenosine 3',5'-diphosphate
GWAS		Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Monocyte percentage of white cells ( 32888494 )	Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Neutrophil count ( 32888494 )
Novel Interactors		2 novel interactors: G3BP1 NDST1	7 novel interactors: ABLIM3 ADAM18 CAMK2A HMGXB3 ITGA11 ST6GALNAC1 SYNPO
Interacting Genes		6 interacting genes: ANXA7 CDK4 CDKN1A PFDN1 SMN1 TK1	2 interacting genes: LCOR RUNX1
Entrez ID		22993	3340
HPRD ID		19515	02912
Ensembl ID		ENSG00000113716	ENSG00000070614
Uniprot IDs		Q12766 Q562E5	A8K8T3 P52848
PDB IDs		Not available	1NST 8CCY 8CD0 8CHS
GO Terms Enriched among Interactors		Response To Phorbol 13-acetate 12-myristate Cyclin Binding Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin-dependent Protein Kinase Holoenzyme Complex PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Ras Protein Signal Transduction Heparan Sulfate N-sulfotransferase Activity Heparan Sulfate N-deacetylase Activity N-acetylglucosamine Deacetylase Activity Thymidine Kinase Activity DNA/RNA Helicase Activity Cyclin D2-CDK4 Complex Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Synthesis Involved In Mitotic DNA Replication Cellular Response To Cell-matrix Adhesion Perikaryon Mitotic Cell Cycle Phase Transition Thymidine Biosynthetic Process Cell Cycle Phase Transition Cellular Response To Ionomycin Oncogene-induced Cell Senescence Stress-induced Premature Senescence Heparin Proteoglycan Biosynthetic Process Prefoldin Complex Thymidine Metabolic Process Positive Regulation Of Stress Granule Assembly Chromaffin Granule Membrane Embryonic Neurocranium Morphogenesis	None