PACS2 and BIRC3

Number of citations of the paper that reports this interaction (PMID 24633224)
0

Data Source:
BioGRID (pull down)

		PACS2	BIRC3
Gene Name		phosphofurin acidic cluster sorting protein 2	baculoviral IAP repeat containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Membrane Raft
	Molecular Function		Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Autophagic Vacuole Assembly Apoptotic Process Viral Process Protein Localization To Pre-autophagosomal Structure Protein Targeting To Plasma Membrane	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Spermatogenesis Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Negative Regulation Of Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Innate Immune Response Regulation Of Inflammatory Response Protein Heterooligomerization Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System
Drugs
Diseases
GWAS			MRI atrophy measures ( 21116278) Prostate cancer ( 23535732)
Protein-Protein Interactions		4 interactors: BIRC2 BIRC3 PKD2 TRAF2	37 interactors: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19
Entrez ID		23241	330
HPRD ID		17816	03426
Ensembl ID		ENSG00000179364	ENSG00000023445
Uniprot IDs		E9PB38 G8JLK3 Q86VP3 Q8N7J0	Q13489
PDB IDs			2UVL 3EB5 3EB6 3M0A 3M0D
Enriched GO Terms of Interacting Partners?		NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Necrotic Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Heterooligomerization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Necrotic Cell Death Positive Regulation Of Innate Immune Response Regulation Of Immune Response Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Cell Death Death Regulation Of Necrotic Cell Death Regulation Of Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Necroptotic Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Positive Regulation Of Interleukin-2 Production Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Protein Oligomerization Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Defense Response To Virus Immune System Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Activation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Immune System Process Apoptotic Process Programmed Cell Death Regulation Of Immune Response Cell Death Death Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Immune System Process Regulation Of Cysteine-type Endopeptidase Activity Defense Response Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Immune Response Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Stress Positive Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		ada3 backbone bak bid conferred cooperatively diablo granzyme hairpin hgrzb kd lentiviral mechanistically mir30 pcaf perforin permeabilization phenocopied pool pores reside screen shrnamir shrnamirs smac tbid toxins transduced unaltered	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Difference) ?		ada3 backbone bak bid conferred cooperatively diablo granzyme hairpin hgrzb kd lentiviral mechanistically mir30 pcaf perforin permeabilization phenocopied pool pores reside screen shrnamir shrnamirs smac tbid toxins transduced unaltered	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Intersection) ?