HNRNPF and MIRLET7C

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		HNRNPF	MIRLET7C
Description		heterogeneous nuclear ribonucleoprotein F	microRNA let-7c
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Plasma Membrane Membrane Synapse Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Extracellular Space Cytoplasm RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Protein Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing Regulation Of RNA Splicing	Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-8 Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Antisaccade task score ( 31596458)
Interacting Genes		156 interacting genes: AKIRIN2 APOBEC1 ATN1 ATP23 AURKA BBS2 C10orf55 C1orf94 CCDC33 CPSF7 DSCAM DUX4 DZIP3 EIF4ENIF1 ERG FAM86C1P HNRNPA0 HNRNPH1 HNRNPH3 HNRNPM HNRNPUL1 HSFY1 HYPK IKZF3 INCA1 IQCE KLF1 KLF15 KPRP KRT75 KRTAP7-1 LASP1 LINC01554 LNX1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL17 MSI1 NCBP1 NCBP2 NDRG1 NFKBID NUDT16L1 OGT PATZ1 PDLIM7 POLR2A PROP1 PRPF40A PRR22 PRR32 PRR34 RBFOX1 RBFOX2 RBM4 REL RNF10 RNF26 RUSC1 SF1 SF3B4 SLAIN1 SMUG1 SNRPC SORBS3 SPATA8 SUMO2 SUMO4 TENT5B TFG TGM2 TGM7 TLE5 TOE1 TRIB3 TRIM14 TXNL4A UNKL USP54 VAV2 VGLL1 VPS37C ZBTB32 ZNF581 ZNF689 ZNF764	96 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CHERP CPSF1 CPSF6 DARS1 DDX1 DDX21 DDX3X DHX36 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RBM4B RBMS2 RTCA RTCB SART3 SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		3185	406885
HPRD ID		03023
Ensembl ID		ENSG00000169813	ENSG00000199030
Uniprot IDs		P52597
PDB IDs		2HGL 2HGM 2HGN 2KFY 2KG0 2KG1 3TFY
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process RNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of MRNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of RNA Stability Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Locomotion Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cytokine Production Regulation Of Cell Migration Involved In Sprouting Angiogenesis	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Splicing Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Nucleus Aminoacyl-tRNA Synthetase Multienzyme Complex Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleoplasm MiRNA Binding Spliceosomal Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Regulation Of Translation Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Stability Negative Regulation Of MRNA Catabolic Process RNA Stabilization TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of MRNA Stability TRNA Aminoacylation MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Nucleolus Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation TRNA Metabolic Process RNA 3'-end Processing Paraspeckles
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