HLF and MYL4

Data Source: HiPPIP (Novel)

		HLF	MYL4
Name		HLF transcription factor, PAR bZIP family member	myosin light chain 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Cytosol Myosin Complex Myosin II Complex A Band
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Actin Monomer Binding Calcium Ion Binding Myosin II Heavy Chain Binding Actin Filament Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	Regulation Of The Force Of Heart Contraction Muscle Contraction Cardiac Muscle Contraction
Pathways		None	Striated Muscle Contraction
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485 ) Bipolar disorder ( 31043756 33263727 ) HDL cholesterol levels ( 32203549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 ) Platelet distribution width ( 32888494 ) Red blood cell count ( 32888494 ) Serum uric acid levels ( 30993211 ) Urate levels ( 23263486 31578528 31985003 ) Urate levels in obese individuals ( 25811787 ) Waist circumference ( 28552196 ) Weight ( 28552196 ) Zinc levels ( 26025379 )	Body mass index ( 26426971 ) Erythema nodosum in inflammatory bowel disease ( 24487271 )
Novel Interactors		5 novel interactors: ABCC3 CCDC59 MYL4 PPAN USO1	2 novel interactors: HLF LOX
Interacting Genes		6 interacting genes: BMAL1 CREBBP DBP HNF4G MYB TET2	1 interacting genes: PYROXD2
Entrez ID		3131	4635
HPRD ID		00797	01176
Ensembl ID		ENSG00000108924	ENSG00000198336
Uniprot IDs		Q16534	P12829
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Golgi Vesicle Docking Icosanoid Transmembrane Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport Energy Homeostasis Histone H3K27 Acetyltransferase Activity Positive Regulation Of Hepatic Stellate Cell Proliferation Myosin II Heavy Chain Binding Oxidative Stress-induced Premature Senescence Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Testosterone Secretion DNA 5-methylcytosine Dioxygenase Activity	Descending Aorta Development Ascending Aorta Development Peptidyl-lysine Oxidation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Bone Development Elastic Fiber Assembly Cellular Response To Chemokine Oxidoreductase Activity Muscle Cell Cellular Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Small Molecule Binding