HLA-DQA2 and HLA-DQB1

Number of citations of the paper that reports this interaction (PMID 9036956)
2

Data Source:
HPRD (in vitro, in vivo)

		HLA-DQA2	HLA-DQB1
Gene Name		major histocompatibility complex, class II, DQ alpha 2	major histocompatibility complex, class II, DQ beta 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	MHC Class II Receptor Activity	MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Alopecia areata ( 20596022) Asthma ( 21804548) Crohn's disease ( 21102463 23266558) Hypothyroidism ( 22493691) IgE levels ( 23146381 22075330) IgG glycosylation ( 23382691) Knee osteoarthritis ( 20305777) Lymphoma ( 23349640) Multiple sclerosis (OCB status) ( 23472185) Narcolepsy ( 20711174) Pulmonary function (interaction) ( 23284291) Rheumatoid arthritis ( 18668548) Systemic lupus erythematosus ( 23053960 21408207) Type 2 diabetes ( 22693455)	Asthma ( 21804548) Celiac disease ( 20190752) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Follicular lymphoma ( 20639881 21533074) Hepatitis B ( 21750111) HPV seropositivity ( 21896673) Hypothyroidism ( 22493691) IgE levels ( 23146381) Knee osteoarthritis ( 20305777) Lymphoma ( 23349640) Multiple sclerosis ( 20453840) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nodular sclerosis Hodgkin lymphoma ( 22086417) Primary biliary cirrhosis ( 19458352 20639880) Prostate cancer ( 23535732) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Systemic sclerosis ( 20383147 21779181) Ulcerative colitis ( 23128233 19122664)
Protein-Protein Interactions		3 interactors: CD4 HLA-DQB1 INS	4 interactors: CD4 CD74 HLA-DQA2 INS
Entrez ID		3118	3119
HPRD ID		09982	05054
Ensembl ID			ENSG00000179344
Uniprot IDs		P01906	P01920 Q5SU54 Q5Y7A9 Q5Y7D3 Q5Y7D6
PDB IDs			1JK8 1NBN 1S9V 1UVQ 2NNA 4GG6
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Immune Response T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Defense Response Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity T Cell Aggregation T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Lymphocyte Aggregation Leukocyte Aggregation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Brown Fat Cell Differentiation Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Feeding Behavior Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Lymphocyte Activation Positive Regulation Of Respiratory Burst Negative Regulation Of Vasodilation Negative Regulation Of Protein Oligomerization Regulation Of Glycogen Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Cell Activation Leukocyte Activation Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of Respiratory Burst Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production	Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Immune System Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Defense Response Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process T Cell Selection Lymphocyte Activation Positive Regulation Of Protein Kinase Activity Regulation Of Cell Activation Leukocyte Activation Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Transferase Activity T Cell Costimulation Regulation Of Cell Adhesion Immune System Process Positive Regulation Of Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Activation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Induction By Virus Of Host Cell-cell Fusion Macrophage Migration Inhibitory Factor Signaling Pathway Protein Palmitoleylation Positive Regulation Of Phosphorylation Antigen Receptor-mediated Signaling Pathway
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