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HLA-DQA2
Gene Name
major histocompatibility complex, class II, DQ alpha 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Lysosomal Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Endosome Membrane
ER To Golgi Transport Vesicle Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
MHC Class II Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
MHC Class II Receptor Activity
Biological Process
Immune Response
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
T Cell Costimulation
T Cell Receptor Signaling Pathway
Interferon-gamma-mediated Signaling Pathway
Pathways
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
Translocation of ZAP-70 to Immunological synapse
Interferon Signaling
Cytokine Signaling in Immune system
Interferon gamma signaling
TCR signaling
MHC class II antigen presentation
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
Drugs
Diseases
GWAS
Alopecia areata (
20596022
)
Asthma (
21804548
)
Crohn's disease (
21102463
23266558
)
Hypothyroidism (
22493691
)
IgE levels (
23146381
22075330
)
IgG glycosylation (
23382691
)
Knee osteoarthritis (
20305777
)
Lymphoma (
23349640
)
Multiple sclerosis (OCB status) (
23472185
)
Narcolepsy (
20711174
)
Pulmonary function (interaction) (
23284291
)
Rheumatoid arthritis (
18668548
)
Systemic lupus erythematosus (
23053960
21408207
)
Type 2 diabetes (
22693455
)
Protein-protein Interactions
3 interactors:
CD4
HLA-DQB1
INS
Entrez ID
3118
HPRD ID
09982
Ensembl ID
Uniprot IDs
P01906
PDB IDs
Enriched GO Terms of Interacting Partners
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T Cell Costimulation
Regulation Of Immune Response
T Cell Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune System Process
Defense Response
Positive Regulation Of T Cell Activation
Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Glycogen Catabolic Process
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Negative Regulation Of NAD(P)H Oxidase Activity
T Cell Aggregation
T Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Lymphocyte Aggregation
Leukocyte Aggregation
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Cytokine Production
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Brown Fat Cell Differentiation
Regulation Of NAD(P)H Oxidase Activity
Negative Regulation Of Feeding Behavior
Regulation Of Lymphocyte Activation
Regulation Of Cellular Amino Acid Metabolic Process
Lymphocyte Activation
Positive Regulation Of Respiratory Burst
Negative Regulation Of Vasodilation
Negative Regulation Of Protein Oligomerization
Regulation Of Glycogen Catabolic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Regulation Of Cell Activation
Leukocyte Activation
Positive Regulation Of Kinase Activity
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Respiratory Burst
Single Organismal Cell-cell Adhesion
Regulation Of Cytokine Production
Tagcloud
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