TCP11L2 and TUBA8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCP11L2	TUBA8
Description		t-complex 11 like 2	tubulin alpha 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Acrosomal Vesicle Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	Protein Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Signal Transduction Muscle Cell Migration	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Spermatogenesis Spermatid Development
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Cargo trafficking to the periciliary membrane RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			Epothilone D Patupilone
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Tourette syndrome ( 22889924)	Atrial fibrillation ( 29892015 30061737) Cerebrospinal T-tau levels ( 28247064)
Interacting Genes		5 interacting genes: APP CXXC1 HGS TUBA4A TUBA8	8 interacting genes: FOXP1 GRM7 LINC01554 MYC PXN SIAH1 TCP1 TCP11L2
Entrez ID		255394	51807
HPRD ID		17555	05763
Ensembl ID		ENSG00000166046	ENSG00000183785
Uniprot IDs		Q8N4U5	Q9NY65
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Early Endosome Membrane Axon Midline Choice Point Recognition Amylin Binding Metal Ion Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Microtubule-based Process Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Structural Constituent Of Cytoskeleton Mitotic Cell Cycle ESCRT-0 Complex Phagocytic Vesicle Lumen Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Microtubule Cytoskeleton Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Unmethylated CpG Binding Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding	Chaperonin-containing T-complex Core Promoter Sequence-specific DNA Binding Regulation Of Monocyte Differentiation Regulation Of B Cell Apoptotic Process ATP-dependent Protein Folding Chaperone Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Telomere Maintenance Group III Metabotropic Glutamate Receptor Activity Myc-Max Complex Regulation Of Acinar Cell Proliferation Positive Regulation Of Interleukin-21 Production
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