HEXA and GM2A

Number of citations of the paper that reports this interaction (PubMedID 9217013)
0

Data Source:
HPRD (in vitro)

		HEXA	GM2A
Description		hexosaminidase subunit alpha	ganglioside GM2 activator
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GO Annotations	Cellular Component	Lysosome Cytosol Membrane Azurophil Granule Lysosomal Lumen Extracellular Exosome Beta-N-acetylhexosaminidase Complex	Extracellular Region Lysosome Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Heterodimerization Activity	Beta-N-acetylhexosaminidase Activity Lipid Transporter Activity Protein Binding Enzyme Activator Activity Phospholipase Activator Activity Hydrolase Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process N-glycan Processing Lipid Metabolic Process Ganglioside Catabolic Process Lysosome Organization Sensory Perception Of Sound Locomotory Behavior Adult Walking Behavior Lipid Storage Sexual Reproduction Glycosaminoglycan Metabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Hyaluronan Catabolic Process Myelination Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Carbohydrate Derivative Metabolic Process	Ganglioside Metabolic Process Lipid Metabolic Process Sphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Glycosphingolipid Catabolic Process Nervous System Process Neuromuscular Process Controlling Balance
Pathways		Keratan sulfate degradation CS/DS degradation Hyaluronan degradation Defective HEXA causes GM2G1 (Hyaluronan metabolism) Glycosphingolipid catabolism	Neutrophil degranulation Glycosphingolipid catabolism
Drugs			Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant	GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS			Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)
Interacting Genes		3 interacting genes: CREBBP GM2A USP22	4 interacting genes: GPLD1 HEXA LCOR PLD2
Entrez ID		3073	2760
HPRD ID		06040	02034
Ensembl ID		ENSG00000213614	ENSG00000196743
Uniprot IDs		A0A0S2Z3W3 B4DVA7 H3BP20 P06865	P17900
PDB IDs		2GJX 2GK1	1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Regulation Of DNA Repair Peptide Lactyltransferase (CoA-dependent) Activity Beta-N-acetylhexosaminidase Activity Histone H2B Deubiquitinase Activity MRF Binding Transcription Coactivator Activity Histone H2A Deubiquitinase Activity Ganglioside Catabolic Process Negative Regulation Of Transcription By RNA Polymerase I N-terminal Protein Amino Acid Acetylation Phospholipase Activator Activity Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Regulation Of DNA Metabolic Process Acetyltransferase Activity Regulation Of Cellular Response To Stress Regulation Of Cellular Response To Heat Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Ceramide Catabolic Process Oligosaccharide Catabolic Process Transcription Factor TFTC Complex Histone Acetyltransferase Complex Chromatin Remodeling Protein-lysine-acetyltransferase Activity Ganglioside Metabolic Process Lipid Transporter Activity SAGA Complex Protein K48-linked Deubiquitination Protein Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Lipid Storage Post-translational Protein Modification Chromatin Organization Sphingolipid Catabolic Process Regulation Of Transcription By RNA Polymerase I Tau Protein Binding Membrane Lipid Catabolic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Neuromuscular Process Controlling Balance	Phospholipase D Activity Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity Filopodium Tip Optic Nerve Morphogenesis Phosphate-containing Compound Metabolic Process Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Detection Of Temperature Stimulus Negative Regulation Of Skeletal Muscle Cell Proliferation Cell Migration In Hindbrain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Skeletal Muscle Cell Differentiation Axon Guidance Receptor Activity Negative Regulation Of Satellite Cell Differentiation Immunological Synapse Formation Detection Of Temperature Stimulus Involved In Sensory Perception Cranial Nerve Morphogenesis Hindbrain Tangential Cell Migration Dendritic Spine Development Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Retinal Ganglion Cell Axon Guidance Dendritic Spine Morphogenesis Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Activity Skeletal Muscle Satellite Cell Activation Lipid Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Sterol Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Phosphatase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Glycerophospholipid Metabolic Process Regulation Of Dephosphorylation Negative Regulation Of Triglyceride Catabolic Process Phospholipid Metabolic Process Response To Triglyceride Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Triglyceride Metabolic Process Hematopoietic Stem Cell Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Triglyceride Biosynthetic Process Cellular Response To Triglyceride Positive Regulation Of Dephosphorylation Immune Response-activating Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Clearance Activation Of Immune Response
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