DNPH1

Description		2'-deoxynucleoside 5'-phosphate N-hydrolase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Identical Protein Binding Protein Homodimerization Activity 5-hydroxymethyl-dUMP N-hydrolase Activity
	Biological Process	Allantoin Metabolic Process Purine Nucleotide Catabolic Process Nucleoside Metabolic Process Nucleotide Metabolic Process Deoxyribonucleoside Monophosphate Catabolic Process Positive Regulation Of Cell Growth Epithelial Cell Differentiation Nucleoside Salvage DGMP Catabolic Process Carbohydrate Derivative Metabolic Process
Pathways		Purine catabolism
Drugs
Diseases
GWAS		Adult hearing difficulty ( 31564434)
Interacting Genes		4 interacting genes: DDIT4L PILRA POT1 TERF1
Entrez ID		10591
HPRD ID		06707
Ensembl ID		ENSG00000112667
Uniprot IDs		O43598
PDB IDs		4P5E 8OS9 8OSC 8QHQ 8QHR 8RPS 8RPT 8RQD 9DA1 9DA2 9DA3 9DA4 9DA5 9DA6
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Chromosome, Telomeric Region 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Positive Regulation Of DNA Metabolic Process Ankyrin Repeat Binding Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Meiotic Telomere Clustering
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