SLC39A2 and SLC30A8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC39A2	SLC30A8
Description		solute carrier family 39 member 2	solute carrier family 30 member 8
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Metal Ion Transmembrane Transporter Activity	Zinc Ion Transmembrane Transporter Activity Protein Binding Zinc Ion Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Protein Homodimerization Activity Metal Ion Binding Zinc:proton Antiporter Activity
	Biological Process	Monoatomic Ion Transport Zinc Ion Transport Metal Ion Transport Keratinocyte Differentiation Transmembrane Transport Cadmium Ion Transmembrane Transport Zinc Ion Transmembrane Transport	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Response To Glucose Response To Zinc Ion Insulin Processing Insulin Secretion Positive Regulation Of Insulin Secretion Response To Type II Interferon Glucose Homeostasis Transmembrane Transport Regulation Of Vesicle-mediated Transport Zinc Ion Import Into Organelle Response To Interleukin-1 Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane
Pathways		Zinc influx into cells by the SLC39 gene family	Insulin processing Zinc efflux and compartmentalization by the SLC30 family
Drugs
Diseases			Type II diabetes mellitus
GWAS			Asthma ( 21814517) Blood sugar levels ( 29403010) Body mass index ( 28892062) Fasting blood glucose ( 33842983 25631608 22581228 20081858) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) Fasting plasma glucose ( 28270201 25187374) Glycated hemoglobin levels ( 24647736 34059833 28898252 19096518) Glycemic traits (pleiotropy) ( 31021400) Hemoglobin A1c levels ( 29403010) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 24002674) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Lung cancer ( 27393504) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Proinsulin levels ( 21873549) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 31217584 29632382 30054458 32499647 31118516 30297969 30718926 26818947 22885922 17460697 17463246 17463248 17463249 19056611 19401414 19734900 20581827 22693455 29358691 23945395 24509480 17293876 26961502 27189021 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Vestibular neuritis ( 30079052)
Interacting Genes		52 interacting genes: AQP1 AQP6 ARL13B ARLN BCL2L2 BTN2A2 C3orf52 CD79A CLCA4 CNR2 COL4A5 COMT CREB3L1 CXCR2 CYB561 EHHADH EMC6 FAM209A FCER1G FXYD3 FXYD6 GJA8 GPR152 GPR42 KCNAB1 KCNAB2 LY6G6C MFSD6 MS4A13 PLN PNLIPRP1 SEC22A SLC18A1 SLC30A2 SLC30A8 SLC39A1 SLC39A9 SLC66A1 SLC7A1 SSMEM1 ST6GAL2 STATH TMEM107 TMEM14B TMEM229B TMEM237 TMEM54 TMEM60 TMEM86A TRHR UPK1B YIPF6	71 interacting genes: ANK1 AQP6 ARL8B ATP13A1 BCL2L13 BSND CCL4 CD99L2 CGRRF1 CMTM7 CPLX4 CREB3L1 DERL1 ELOVL4 ERVFRD-1 FAM209A FAM210B FAXDC2 FCER1G GPR37L1 GPR42 GRM2 HMOX2 HSD17B11 JSRP1 LEUTX LMNA MUC1 NKG7 ORMDL1 OTULINL PCNA PGRMC2 PKMYT1 PLN PSCA PTPN9 REEP4 REEP6 RELL2 RMDN3 RTN3 RUSF1 SCN3B SELENOK SFT2D1 SFT2D2 SLC18A1 SLC30A3 SLC39A2 SNCA SYS1 SYT2 THAP4 THSD7B TMEM11 TMEM139 TMEM14B TMEM208 TMEM237 TMEM31 TMEM50A TMEM52B TMEM80 TMEM9 TSPAN2 VAMP1 VAMP2 YIPF4 YIPF6 ZFYVE27
Entrez ID		29986	169026
HPRD ID		15385	15370
Ensembl ID		ENSG00000165794	ENSG00000164756
Uniprot IDs		Q9NP94	Q8IWU4
PDB IDs			6XPD 6XPE 6XPF
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Monoatomic Ion Transport Zinc Ion Transmembrane Transporter Activity Inorganic Ion Transmembrane Transport Zinc Ion Transport Zinc Ion Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Lysine Transport Potassium Ion Transport Inorganic Cation Transmembrane Transport Protein Binding Plasma Membrane Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Zinc:proton Antiporter Activity Monoamine Transport Intracellular Zinc Ion Homeostasis Monoatomic Cation Transmembrane Transport L-lysine Transmembrane Transport Organic Cation Transport Ion Channel Regulator Activity Renal Water Transport Norepinephrine Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Neural Tube Patterning Channel Activity Ammonium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Ammonium Transmembrane Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Response To Zinc Ion Aromatic Amino Acid Transport Zinc Ion Import Into Organelle L-arginine Transmembrane Transport Transport Vesicle Membrane Serotonin Transport Azole Transmembrane Transport Juxtaparanode Region Of Axon Alcohol Dehydrogenase (NADP+) Activity External Side Of Plasma Membrane Water Channel Activity Carbon Dioxide Transport	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Vesicle-mediated Transport Regulated Exocytosis SNARE Complex Assembly Exocytosis Synaptic Vesicle Membrane Secretion By Cell Endoplasmic Reticulum Tubular Network Organization Cytolytic Granule Membrane Endoplasmic Reticulum Organization Protein Localization To Plasma Membrane SNARE Binding Clathrin-sculpted Monoamine Transport Vesicle Membrane Monoamine Transport Endoplasmic Reticulum Tubular Network Formation Secretion Protein Localization To Cell Periphery Membrane Organization Natural Killer Cell Degranulation Synaptic Vesicle Exocytosis Synapse Regulation Of Vesicle Fusion Establishment Of Localization In Cell Leukocyte Degranulation Terminal Bouton Positive Regulation Of Lymphocyte Migration Vesicle Fusion Endomembrane System Catecholamine Uptake Dopamine Uptake SNARE Complex Organelle Membrane Fusion
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