SLC30A8 and OTULINL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC30A8	OTULINL
Description		solute carrier family 30 member 8	OTU deubiquitinase with linear linkage specificity like
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Zinc Ion Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Protein Homodimerization Activity Metal Ion Binding Zinc:proton Antiporter Activity	Protein Binding Ubiquitin-like Protein Peptidase Activity Ubiquitin Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Response To Glucose Response To Zinc Ion Insulin Processing Insulin Secretion Positive Regulation Of Insulin Secretion Response To Type II Interferon Glucose Homeostasis Transmembrane Transport Regulation Of Vesicle-mediated Transport Zinc Ion Import Into Organelle Response To Interleukin-1 Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane	Protein Deubiquitination
Pathways		Insulin processing Zinc efflux and compartmentalization by the SLC30 family
Drugs
Diseases		Type II diabetes mellitus
GWAS		Asthma ( 21814517) Blood sugar levels ( 29403010) Body mass index ( 28892062) Fasting blood glucose ( 33842983 25631608 22581228 20081858) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) Fasting plasma glucose ( 28270201 25187374) Glycated hemoglobin levels ( 24647736 34059833 28898252 19096518) Glycemic traits (pleiotropy) ( 31021400) Hemoglobin A1c levels ( 29403010) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 24002674) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Lung cancer ( 27393504) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Proinsulin levels ( 21873549) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 31217584 29632382 30054458 32499647 31118516 30297969 30718926 26818947 22885922 17460697 17463246 17463248 17463249 19056611 19401414 19734900 20581827 22693455 29358691 23945395 24509480 17293876 26961502 27189021 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Vestibular neuritis ( 30079052)	Asthma ( 32296059 34103634)
Interacting Genes		71 interacting genes: ANK1 AQP6 ARL8B ATP13A1 BCL2L13 BSND CCL4 CD99L2 CGRRF1 CMTM7 CPLX4 CREB3L1 DERL1 ELOVL4 ERVFRD-1 FAM209A FAM210B FAXDC2 FCER1G GPR37L1 GPR42 GRM2 HMOX2 HSD17B11 JSRP1 LEUTX LMNA MUC1 NKG7 ORMDL1 OTULINL PCNA PGRMC2 PKMYT1 PLN PSCA PTPN9 REEP4 REEP6 RELL2 RMDN3 RTN3 RUSF1 SCN3B SELENOK SFT2D1 SFT2D2 SLC18A1 SLC30A3 SLC39A2 SNCA SYS1 SYT2 THAP4 THSD7B TMEM11 TMEM139 TMEM14B TMEM208 TMEM237 TMEM31 TMEM50A TMEM52B TMEM80 TMEM9 TSPAN2 VAMP1 VAMP2 YIPF4 YIPF6 ZFYVE27	10 interacting genes: AQP6 GOLT1A HSD17B11 JAGN1 RETREG3 SLC30A8 TMEM14B TMEM31 TMEM86B TMX2
Entrez ID		169026	54491
HPRD ID		15370	07733
Ensembl ID		ENSG00000164756	ENSG00000145569
Uniprot IDs		Q8IWU4	Q9NUU6
PDB IDs		6XPD 6XPE 6XPF	6DRM
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Vesicle-mediated Transport Regulated Exocytosis SNARE Complex Assembly Exocytosis Synaptic Vesicle Membrane Secretion By Cell Endoplasmic Reticulum Tubular Network Organization Cytolytic Granule Membrane Endoplasmic Reticulum Organization Protein Localization To Plasma Membrane SNARE Binding Clathrin-sculpted Monoamine Transport Vesicle Membrane Monoamine Transport Endoplasmic Reticulum Tubular Network Formation Secretion Protein Localization To Cell Periphery Membrane Organization Natural Killer Cell Degranulation Synaptic Vesicle Exocytosis Synapse Regulation Of Vesicle Fusion Establishment Of Localization In Cell Leukocyte Degranulation Terminal Bouton Positive Regulation Of Lymphocyte Migration Vesicle Fusion Endomembrane System Catecholamine Uptake Dopamine Uptake SNARE Complex Organelle Membrane Fusion	Endoplasmic Reticulum Insulin Metabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Insulin Secretion Peptide Hormone Secretion Endoplasmic Reticulum Organization Peptide Secretion D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Hormone Secretion Carbon Dioxide Transmembrane Transporter Activity Membrane Carbon Dioxide Transmembrane Transport Endoplasmic Reticulum Membrane Steroid Dehydrogenase Activity Androgen Catabolic Process Regulation Of Hormone Levels Protein Localization To Extracellular Region Granulocyte Colony-stimulating Factor Signaling Pathway Response To Monosaccharide Hormone Transport Establishment Of Protein Localization To Extracellular Region Response To Glucose Protein Secretion Amide Transport Peptide Transport Endoplasmic Reticulum-autophagosome Adaptor Activity Zinc:proton Antiporter Activity Monoatomic Anion Channel Activity Ammonium Channel Activity Renal Water Transport Disulfide Oxidoreductase Activity Mitochondrial Membrane Hormone Metabolic Process Estrogen Biosynthetic Process Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Insulin Secretion Response To Carbohydrate Signal Release Neutrophil Differentiation Substrate Localization To Autophagosome Zinc Ion Import Across Plasma Membrane Insulin Processing Ammonium Transmembrane Transport Regulation Of Peptide Hormone Secretion Zinc Ion Import Into Organelle Golgi Cis Cisterna
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