SLC30A8 and CD99L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC30A8	CD99L2
Description		solute carrier family 30 member 8	CD99 molecule like 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle	Extracellular Region Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Anchoring Junction
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Zinc Ion Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Protein Homodimerization Activity Metal Ion Binding Zinc:proton Antiporter Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Response To Glucose Response To Zinc Ion Insulin Processing Insulin Secretion Positive Regulation Of Insulin Secretion Response To Type II Interferon Glucose Homeostasis Transmembrane Transport Regulation Of Vesicle-mediated Transport Zinc Ion Import Into Organelle Response To Interleukin-1 Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane	Cell Adhesion Diapedesis Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T Cell Extravasation
Pathways		Insulin processing Zinc efflux and compartmentalization by the SLC30 family	Cell surface interactions at the vascular wall
Drugs
Diseases		Type II diabetes mellitus
GWAS		Asthma ( 21814517) Blood sugar levels ( 29403010) Body mass index ( 28892062) Fasting blood glucose ( 33842983 25631608 22581228 20081858) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) Fasting plasma glucose ( 28270201 25187374) Glycated hemoglobin levels ( 24647736 34059833 28898252 19096518) Glycemic traits (pleiotropy) ( 31021400) Hemoglobin A1c levels ( 29403010) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 24002674) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Lung cancer ( 27393504) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Proinsulin levels ( 21873549) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 31217584 29632382 30054458 32499647 31118516 30297969 30718926 26818947 22885922 17460697 17463246 17463248 17463249 19056611 19401414 19734900 20581827 22693455 29358691 23945395 24509480 17293876 26961502 27189021 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Vestibular neuritis ( 30079052)	Glycated hemoglobin levels ( 34059833)
Interacting Genes		71 interacting genes: ANK1 AQP6 ARL8B ATP13A1 BCL2L13 BSND CCL4 CD99L2 CGRRF1 CMTM7 CPLX4 CREB3L1 DERL1 ELOVL4 ERVFRD-1 FAM209A FAM210B FAXDC2 FCER1G GPR37L1 GPR42 GRM2 HMOX2 HSD17B11 JSRP1 LEUTX LMNA MUC1 NKG7 ORMDL1 OTULINL PCNA PGRMC2 PKMYT1 PLN PSCA PTPN9 REEP4 REEP6 RELL2 RMDN3 RTN3 RUSF1 SCN3B SELENOK SFT2D1 SFT2D2 SLC18A1 SLC30A3 SLC39A2 SNCA SYS1 SYT2 THAP4 THSD7B TMEM11 TMEM139 TMEM14B TMEM208 TMEM237 TMEM31 TMEM50A TMEM52B TMEM80 TMEM9 TSPAN2 VAMP1 VAMP2 YIPF4 YIPF6 ZFYVE27	9 interacting genes: CREB3L1 SGTA SGTB SLC30A2 SLC30A8 TMBIM6 TRAM1L1 UBQLN1 UBQLN2
Entrez ID		169026	83692
HPRD ID		15370	06469
Ensembl ID		ENSG00000164756	ENSG00000102181
Uniprot IDs		Q8IWU4	A0A024RC16 Q8TCZ2
PDB IDs		6XPD 6XPE 6XPF
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Vesicle-mediated Transport Regulated Exocytosis SNARE Complex Assembly Exocytosis Synaptic Vesicle Membrane Secretion By Cell Endoplasmic Reticulum Tubular Network Organization Cytolytic Granule Membrane Endoplasmic Reticulum Organization Protein Localization To Plasma Membrane SNARE Binding Clathrin-sculpted Monoamine Transport Vesicle Membrane Monoamine Transport Endoplasmic Reticulum Tubular Network Formation Secretion Protein Localization To Cell Periphery Membrane Organization Natural Killer Cell Degranulation Synaptic Vesicle Exocytosis Synapse Regulation Of Vesicle Fusion Establishment Of Localization In Cell Leukocyte Degranulation Terminal Bouton Positive Regulation Of Lymphocyte Migration Vesicle Fusion Endomembrane System Catecholamine Uptake Dopamine Uptake SNARE Complex Organelle Membrane Fusion	Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress TRC Complex Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Response To Endoplasmic Reticulum Stress Zinc:proton Antiporter Activity Regulation Of Cellular Response To Stress Zinc Ion Import Into Organelle Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Monoatomic Cation Transmembrane Transporter Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Zinc Ion Transport Protein Insertion Into ER Membrane Protein Targeting To ER Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Zinc Ion Homeostasis Positive Regulation Of Proteolysis Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Protein Catabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transport Polyubiquitin Modification-dependent Protein Binding Membrane Response To Zinc Ion Transport Vesicle Membrane Negative Regulation Of Calcium Ion Transport Autophagy Endoplasmic Reticulum Unfolded Protein Response Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Negative Regulation Of Store-operated Calcium Channel Activity Protein Insertion Into Membrane Protein Targeting To Membrane Cellular Response To Stress Negative Regulation Of Cation Transmembrane Transport Cytoplasmic Vesicle Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Protein Catabolic Process Autophagosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?